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Wearable Assisted Viral Evidence (WAVE) Study A Decentralized, Prospective Study Exploring the Relationship...
Evidation Health
Influenza, Human
COVID-19
Influenza A
Influenza B
Respiratory Syncytial Virus (RSV)
The goal of this decentralized, observational study is to enroll and observe adults in
the contingent United States during the 2023-2024 flu season. The main study objectives
are to create a dataset of paired wearable data, self-reported symptoms, and respiratory
viral infection (RVI) from PCR testing... expand
The goal of this decentralized, observational study is to enroll and observe adults in the contingent United States during the 2023-2024 flu season. The main study objectives are to create a dataset of paired wearable data, self-reported symptoms, and respiratory viral infection (RVI) from PCR testing during the 2023-2024 flu season and to develop algorithm that is able to accurately classify asymptomatic and symptomatic RVI and understand the algorithm's performance metrics. Type: Observational Start Date: Jan 2024 |
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans...
National Human Genome Research Institute (NHGRI)
Heart Disease
Background:
The COVID-19 pandemic infected and killed African Americans at higher rates than other
Americans. Researchers want to understand why.
Objective:
This natural history study will look at how genetic, environmental, and social factors
may predict or affect COVID-19 in African Americans.... expand
Background: The COVID-19 pandemic infected and killed African Americans at higher rates than other Americans. Researchers want to understand why. Objective: This natural history study will look at how genetic, environmental, and social factors may predict or affect COVID-19 in African Americans. Information from this study will be combined with data from the GENE-FORECAST study. Eligibility: African Americans who were previously enrolled in GENE-FORECAST. Design: The study includes a telephone interview and 1 visit to the NIH clinic. Participants may engage in either one or both of these activities. The telephone interview will last 20 minutes. Participants will talk about their experiences during the COVID-19 pandemic. The clinic visit will last up to 4 hours. Participants will have a physical exam. They will have blood and urine tests. They will be tested for COVID-19. A long swab will be inserted into a nostril to get a fluid sample from the back of the nose. They will have noninvasive tests of their blood vessels. One device used is a pen-like probe placed lightly on the wrist. Another is a rubber sleeve placed around a finger while a blood pressure cuff is used on the arm. Participants will have a test to measure the electrical activity in their heart. Stickers attached to wires will be placed on their chest, arms, and legs. Participants will answer more questions about COVID-19. They will talk about their health behavior. They will talk about their family's health and the neighborhood they live in. Other questions will ask how they feel, live, work, and play.... Type: Observational Start Date: Feb 2023 |
COVID-19 Self-testing IMPROVE
Temple University
COVID-19
The study aims to engage community partners to implement IMPROVE intervention and promote
(COVID-19) rapid testing among vulnerable Asian Americans in the Greater Philadelphia
Area and New York City expand
The study aims to engage community partners to implement IMPROVE intervention and promote (COVID-19) rapid testing among vulnerable Asian Americans in the Greater Philadelphia Area and New York City Type: Interventional Start Date: Jun 2023 |
Evaluating the Effects of a Fermented Diet on Microbiome Diversity in Individuals With Long COVID
Mayo Clinic
Long COVID
The purpose of this study is to evaluate the effects of fermented foods on bacterial gut
microbiome diversity of long-COVID subjects. expand
The purpose of this study is to evaluate the effects of fermented foods on bacterial gut microbiome diversity of long-COVID subjects. Type: Interventional Start Date: Aug 2024 |
Cardiopulmonary Exercise Tests in Patients With Long COVID
Sheffield Hallam University
Long COVID
COVID Long-Haul
The value of clinical cardiopulmonary exercise testing (CPET) within healthcare settings
has been established in the last decade. CPET methods remain highly relevant in the
COVID-19 endemic phase and should be used to assess those recovering from COVID-19
(SARS-CoV-2) infection. This diagnostic tool... expand
The value of clinical cardiopulmonary exercise testing (CPET) within healthcare settings has been established in the last decade. CPET methods remain highly relevant in the COVID-19 endemic phase and should be used to assess those recovering from COVID-19 (SARS-CoV-2) infection. This diagnostic tool could play an integral role in disease prognostication and evaluate the integrative response to incremental exercise. Date from such assessments can enable practitioners to characterise cardio-respiratory fitness and identify reasons for physical impairment or abnormal cardio-respiratory function. More than 50% of patients admitted to hospital will experience cardiorespiratory issues and significant morbidity during their recovery and will require significant rehabilitative support. In this context, measurements obtained from an assessment of cardio-respiratory responses to physiological stress could provide insight regarding the integrity of the pulmonary-vascular interface and characterisation of any impairment or abnormal cardio-respiratory function. Current approaches to rehabilitation are being developed on existing knowledge from Severe Acute Respiratory Syndrome (SARS) and Acute Respiratory Distress Syndrome (ARDS) related illness. These provide important insight but do not provide insight into the novel challenges provided by COVID-19. Type: Observational Start Date: Mar 2023 |
Xofluza-Wearables Feasibility-Study
Children's Hospital of Philadelphia
Infection, Coronavirus
Infections
Influenza
Transplant
Infection Viral
The goal of this prospective, interventional, single-center study is to assess whether
the early detection of Influenza with smartwatch algorithms and alerting, rapid testing,
and subsequent Baloxavir treatment demonstrate better post-infection outcomes versus
publicly available- and Centers for Disease... expand
The goal of this prospective, interventional, single-center study is to assess whether the early detection of Influenza with smartwatch algorithms and alerting, rapid testing, and subsequent Baloxavir treatment demonstrate better post-infection outcomes versus publicly available- and Centers for Disease Control (CDC)-derived national statistics for equivalent household populations as well as pediatric kidney, heart, liver, lung transplant recipients and waitlisted patients. Type: Interventional Start Date: Dec 2023 |
RECOVER-NEURO: Platform Protocol to Measure the Effects of Cognitive Dysfunction Interventions on Long...
Duke University
Long COVID
Long Covid19
Long Covid-19
This platform protocol is designed to be flexible so that it is suitable for a wide range
of settings within health care systems, for remote settings, and in community settings
where it can be integrated into COVID-19 programs and subsequent treatment plans.
This protocol is a prospective, multi-center,... expand
This platform protocol is designed to be flexible so that it is suitable for a wide range of settings within health care systems, for remote settings, and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating potential interventions for PASC-mediated cognitive dysfunction. The hypothesis is that PASC associated dysfunction in cognitive domains, such as executive function and attention, may be improved by interventions that selectively focus on enhancing those domains. Type: Interventional Start Date: Sep 2023 |
RECOVER-NEURO: Platform Protocol, Appendix_A to Measure the Effects of BrainHQ, PASC CoRE and tDCS Interventions...
Duke University
Long COVID
Long Covid19
Long Covid-19
This platform protocol is designed to be flexible so that it is suitable for a wide range
of settings within health care systems, for remote settings, and in community settings
where it can be integrated into COVID-19 programs and subsequent treatment plans.
This protocol is a prospective, multi-center,... expand
This platform protocol is designed to be flexible so that it is suitable for a wide range of settings within health care systems, for remote settings, and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating potential interventions for PASC-mediated cognitive dysfunction. The hypothesis is that PASC-associated dysfunction in cognitive domains, such as executive function and attention, may be improved by interventions that selectively focus on enhancing those domains. This design seeks to evaluate each intervention relative to the Active Comparator. The BrainHQ (alone) arm is important because the intervention is commercially available, accessible, relatively inexpensive, and does not require trained personnel to administer. BrainHQ has been also been proven effective in other studies of cognitive dysfunction such as studies in aging, mild cognitive impairment, traumatic brain injury, among others. The BrainHQ + PASC CoRE arm and the BrainHQ + tDCS arms are suspected to provide cognitive improvements beyond BrainHQ alone through different mechanisms. Both PASC CoRE and tDCS have extensive prior use and have demonstrated utility in improving aspects of cognitive function in other clinical settings.. Type: Interventional Start Date: Sep 2023 |
Sauna for Long Covid
Massachusetts General Hospital
Long COVID
Research suggests that Whole Body Hyperthermia in a sauna-like environment can reduce
symptoms related to post-acute sequelae of SARS-CoV-2 (PASC), or Long Covid. The
investigators aim to study the feasibility and treatment effect of this procedure for
patients experiencing Long Covid symptoms. expand
Research suggests that Whole Body Hyperthermia in a sauna-like environment can reduce symptoms related to post-acute sequelae of SARS-CoV-2 (PASC), or Long Covid. The investigators aim to study the feasibility and treatment effect of this procedure for patients experiencing Long Covid symptoms. Type: Interventional Start Date: Sep 2024 |
Long-Term Sequelae of SARS-COV-2 Infection: Diabetes Mellitus
The University of Texas Health Science Center at San Antonio
COVID-19
Diabete Mellitus
Hospitalized patients with severe COVID-19 have an increased incidence of insulin
resistance, impaired beta cell function, glucose intolerance (prediabetes), and overt
type 2 diabetes (T2D) compared to non-hospitalized patients with COVID-19 and COVID-19
negative individuals on long-term follow up. expand
Hospitalized patients with severe COVID-19 have an increased incidence of insulin resistance, impaired beta cell function, glucose intolerance (prediabetes), and overt type 2 diabetes (T2D) compared to non-hospitalized patients with COVID-19 and COVID-19 negative individuals on long-term follow up. Type: Observational Start Date: Jul 2023 |
Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation...
University of Minnesota
COVID-19
COVID-19 can trigger a dysregulated immune response, and previous studies have shown that
immune modulation can improve outcomes in hospitalized patients. This trial is designed
to determine whether intensification of immune modulation early in the course of the
disease (while patients are on low... expand
COVID-19 can trigger a dysregulated immune response, and previous studies have shown that immune modulation can improve outcomes in hospitalized patients. This trial is designed to determine whether intensification of immune modulation early in the course of the disease (while patients are on low flow oxygen) with abatacept (active arm) combined with standard of care (SOC) improves recovery as compared with placebo + SOC (placebo arm). For both groups, intensification of immunomodulation will be provided as part of SOC in case of signs of disease progression (patient requires high flow nasal oxygen (HFNO) or more support) and/or if the patient has rapidly increasing oxygen requirement. Type: Interventional Start Date: Jul 2023 |
The Impact of Chiropractic on Long COVID-19
Life University
Long COVID
The purpose of this waitlist-controlled, single-blind, one-way crossover, pilot trial is
to evaluate the potential effects of ~8 weeks of chiropractic care on patient-reported
fatigue and the autonomic nervous system in adults with long COVID. This study will allow
us to estimate the standard deviation... expand
The purpose of this waitlist-controlled, single-blind, one-way crossover, pilot trial is to evaluate the potential effects of ~8 weeks of chiropractic care on patient-reported fatigue and the autonomic nervous system in adults with long COVID. This study will allow us to estimate the standard deviation of the primary endpoint in our population with which a formal power calculation for a future randomized, controlled trial can be performed. Type: Interventional Start Date: Jan 2025 |
Pain in Long COVID-19: The Role of Sleep
Beth Israel Deaconess Medical Center
Long COVID
Pain is among the most frequently reported symptoms in Long COVID, along with sleep
disturbances, fatigue, and cognitive impairments. Sleep plays a critical role in
maintaining a pain-free state. The goal of this study is to characterize the type and
severity of pain in Long COVID, to characterize... expand
Pain is among the most frequently reported symptoms in Long COVID, along with sleep disturbances, fatigue, and cognitive impairments. Sleep plays a critical role in maintaining a pain-free state. The goal of this study is to characterize the type and severity of pain in Long COVID, to characterize sleep and sleep disturbances in Long COVID, and to understand the role of sleep in the development and persistence of pain symptoms in Long COVID. Type: Observational Start Date: Oct 2022 |
A Safety and Tolerability Study of Sotrovimab (VIR-7831) Prophylaxis Against COVID-19 in Immunocompromised...
Sophia Koo, M.D.
SARS CoV 2 Infection
This is an open-label study examining the safety and tolerability of sotrovimab,
administered in two sequential doses as prophylaxis in immunocompromised patients with
impaired humoral immunity against SARS-CoV-2. expand
This is an open-label study examining the safety and tolerability of sotrovimab, administered in two sequential doses as prophylaxis in immunocompromised patients with impaired humoral immunity against SARS-CoV-2. Type: Interventional Start Date: Feb 2022 |
Frontline Clinician Psilocybin Study
University of Washington
Burnout, Caregiver
Burnout, Professional
COVID-19
Depression
Post Traumatic Stress Disorder
This study aims to investigate the effects of a single dose of psilocybin, delivered in
the contextof pre- and post-dose psychotherapy, on symptoms of depression and burnout
suffered by healthcare clinicians as a result of frontline work in the COVID pandemic. expand
This study aims to investigate the effects of a single dose of psilocybin, delivered in the contextof pre- and post-dose psychotherapy, on symptoms of depression and burnout suffered by healthcare clinicians as a result of frontline work in the COVID pandemic. Type: Interventional Start Date: Mar 2022 |
A Study of Acute Respiratory Infections in Global Outpatient Setting
Janssen Research & Development, LLC
Acute Respiratory Infection
The purpose of this study is to evaluate the positivity rate of respiratory syncytial
virus (RSV), influenza virus and severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in high-risk participants presenting with acute respiratory infections
(ARIs) in outpatient settings during the influenza/RSV... expand
The purpose of this study is to evaluate the positivity rate of respiratory syncytial virus (RSV), influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in high-risk participants presenting with acute respiratory infections (ARIs) in outpatient settings during the influenza/RSV season and to evaluate the association between lower respiratory tract disease (LRTD) and ARI-related hospitalization in participants positive for RSV. Type: Interventional Start Date: Dec 2021 |
A Trial of the Safety and Immunogenicity of the COVID-19 Vaccine (mRNA-1273) in Participants With Hematologic...
National Cancer Institute (NCI)
Solid Tumor Malignancy
Hematologic Malignancy
Leukemia
Lymphoma
Multiple Myeloma
Background:
Coronavirus disease (COVID-19) is a viral infection. It has spread rapidly across the
globe. It has overwhelmed health systems. Researchers are concerned that it may undo
years of progress in the reduction of cancer-specific death. They want to test a vaccine
that might protect people... expand
Background: Coronavirus disease (COVID-19) is a viral infection. It has spread rapidly across the globe. It has overwhelmed health systems. Researchers are concerned that it may undo years of progress in the reduction of cancer-specific death. They want to test a vaccine that might protect people with cancer from COVID-19. Objective: To test the safety and efficacy of a vaccine using messenger ribonucleic acid (mRNA)-1273 that may protect people with cancer from COVID-19. Eligibility: Adults ages 18 and older who have a solid tumor or blood cancer and who may benefit from a vaccine that might prepare their immune system for fighting and preventing infection from COVID-19. Patients with solid tumors must be receiving treatment with an immunotherapy agent. Design: Participants will be screened with a medical history, medicine review, and physical exam. They will have blood tests. They will have a pregnancy test if needed. Participants will get 2 doses of the mRNA-1273 vaccine if they have not been vaccinated already. It will be injected into a muscle in the arm on Days 1 and 29. They will be followed for 12 months after the second dose. Participants will have study visits at the Clinical Center on Days 1, 29, 36,57, 209, and 394. Some visits will last about 4-6 hours. Patients will be able to get up to 3 doses of mRNA-1273 as a booster on trial if they have already completed a primary series of a vaccine. Participants who have already received a booster dose of vaccine will be able to enroll to receive additional boosters. It will be injected into a muscle in the arm on Day 1. Participants will be followed for 12 months after their last booster injection. Participants who receive booster doses will have study visits at the Clinical Center on Days 1, 29, 57, 180 and 360. Participants will give blood and saliva samples for research. Participation will last about 16 months. Type: Interventional Start Date: Apr 2021 |
Prophylaxis and Treatment of COVID-19
Henry M. Jackson Foundation for the Advancement of Military Medicine
COVID-19
Acute Respiratory Infection
An observation study evaluating physiologic responses and host biomarker expression
patterns in early SARS-CoV-2 and acute respiratory infections (ARI) and among their close
contacts. expand
An observation study evaluating physiologic responses and host biomarker expression patterns in early SARS-CoV-2 and acute respiratory infections (ARI) and among their close contacts. Type: Observational Start Date: Jun 2021 |
A Study of Risk Factors for the COVID-19 Virus Infection
Memorial Sloan Kettering Cancer Center
COVID-19 Infections in Cancer Patients
The purpose of this study is to collect information that will help the reasearchers learn
more about COVID-19 infections in cancer patients, and to find out about the effects of
these infections on cancer treatment and outcomes. The research study involves asking
people to complete a series of online... expand
The purpose of this study is to collect information that will help the reasearchers learn more about COVID-19 infections in cancer patients, and to find out about the effects of these infections on cancer treatment and outcomes. The research study involves asking people to complete a series of online questionnaires that include questions about their medical history, lifestyle, and risk factors related to the COVID-19 infection. The study will enroll both MSK patients and their household family members. Type: Observational Start Date: Dec 2020 |
COVID-19 Biorepository
University of Kansas Medical Center
Covid-19
SARS-CoV 2
Coronavirus
COVID
Establish a COVID-19 biorepository to aid in developing our knowledge of the disease. expand
Establish a COVID-19 biorepository to aid in developing our knowledge of the disease. Type: Observational Start Date: Apr 2020 |
Trial of Imatinib for Hospitalized Adults With COVID-19
University of Maryland, Baltimore
COVID-19
This study is a randomized Double-Blind Placebo-Controlled Trial on the Safety and
Efficacy of Imatinib for Hospitalized Adults with COVID-19 expand
This study is a randomized Double-Blind Placebo-Controlled Trial on the Safety and Efficacy of Imatinib for Hospitalized Adults with COVID-19 Type: Interventional Start Date: Jun 2020 |
COVID-19 CHAMPS Study of Healthcare, First Responder and Service Workers
Villanova University
Occupational Exposure to SARS-CoV-2
COVID-19
The COVID-19 CHAMPS Study will obtain data on the physical and mental health and
well-being of workers potentially exposed to the SARS-CoV-2 virus in the course of their
duties. Included are a broad range of occupations including those working in the
community (police officers, firefighters, emergency... expand
The COVID-19 CHAMPS Study will obtain data on the physical and mental health and well-being of workers potentially exposed to the SARS-CoV-2 virus in the course of their duties. Included are a broad range of occupations including those working in the community (police officers, firefighters, emergency personnel, screening staff) as well as in permanent or temporary sites that care for patients (service staff, nurses, physicians and other health professionals). CHAMPS will obtain data on various exposure factors and health and create a registry of participants for extended follow up and sub-studies. Type: Observational [Patient Registry] Start Date: May 2020 |
Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients
Novartis Pharmaceuticals
Sickle Cell Disease (SCD)
The purpose of the Phase 2 CSEG101B2201 study is to confirm and to establish appropriate
dosing and to evaluate the safety in pediatric participants ages 6 months to <18 years
with a history of VOC with or without HU/HC, receiving crizanlizumab for 2 years. The
efficacy and safety of crizanlizumab... expand
The purpose of the Phase 2 CSEG101B2201 study is to confirm and to establish appropriate dosing and to evaluate the safety in pediatric participants ages 6 months to <18 years with a history of VOC with or without HU/HC, receiving crizanlizumab for 2 years. The efficacy and safety of crizanlizumab was already demonstrated in adults with sickle cell disease. The approach is to extrapolate from the PK/pharmacodynamics (PD) already established in the adult population. The study is designed as a Phase II, multicenter, open-label study. Type: Interventional Start Date: Oct 2018 |
Natural History Study of COVID-19 Using Digital Wearables
National Institute on Minority Health and Health Disparities (NIMHD)
COVID-19 Virus Disease
Background:
People with COVID-19 have varying degrees of illness. It can range from no or mild
symptoms to critical illness and death. Some people with COVID-19 have long-term effects
regardless of the severity of their disease initially. Researchers want to learn more to
see if they can better... expand
Background: People with COVID-19 have varying degrees of illness. It can range from no or mild symptoms to critical illness and death. Some people with COVID-19 have long-term effects regardless of the severity of their disease initially. Researchers want to learn more to see if they can better predict where a person may fall on the illness spectrum. Objective: To follow and record symptoms of COVID-19 to see how it progresses in people and why some people stay sick longer than others. Eligibility: People ages 18-65 who received a COVID-19 positive test result in the 72 hours before their enrollment in the study. Design: Participants will complete a 30-minute baseline survey. They will answer questions about themselves and their health. Participants will get a digital wristband and temperature sensor in the mail. They will get instructions on how to set up and wear the devices. They will download a mobile application on their phone. The app will collect data from the devices. Participants will wear the wristband and sensor every day for the first month. Then they will wear the devices for a total of 40 days over the next 5 months. On the days they wear the devices, they will answer a 2-question health survey via the app. Participants will answer a 20-minute online survey about their health every 30 days. If participants are hospitalized, a family member or close friend will be asked to complete a brief 7-minute online survey about their hospital stay and treatment. Participants will be sent alerts and reminders throughout the study. Participation will last for 6 months. Type: Observational Start Date: Oct 2021 |
Improving Attention in Individuals With Long COVID-19
Shirley Ryan AbilityLab
Long Covid
This study is to find out if the Attention Processing Training program is a potential
treatment for brain fog symptoms, reported by people with Long-Covid. Also investigating
the feasibility of completing this program virtually. expand
This study is to find out if the Attention Processing Training program is a potential treatment for brain fog symptoms, reported by people with Long-Covid. Also investigating the feasibility of completing this program virtually. Type: Interventional Start Date: Mar 2024 |
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