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Purpose

Hospitalized patients with severe COVID-19 have an increased incidence of insulin resistance, impaired beta cell function, glucose intolerance (prediabetes), and overt type 2 diabetes (T2D) compared to non-hospitalized patients with COVID-19 and COVID-19 negative individuals on long-term follow up.

Conditions

Eligibility

Eligible Ages
Between 18 Years and 75 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Body Mass index (BMI) < 40 kg/m2

Exclusion Criteria

  • History of diabetes prior to SARS-CoV-2 infection - Took medications used to treat diabetes prior to SARS-CoV-2 infection - History of myocardial infarction or stroke within 6 months - History of major organ system disease prior to COVID-19 infection

Study Design

Phase
Study Type
Observational
Observational Model
Other
Time Perspective
Other

Arm Groups

ArmDescriptionAssigned Intervention
Severe COVID-19 Group Hospitalized in ICU with COVID-19 (PCR positive) and recovered
  • Other: Measure of physiologic parameters
    Participants will have hepatic muscle and adipose tissue insulin sensitivity tested
Mild COVID-19 positive Group COVID-19 positive (by PCR) who recovered from mild COVID-19 and were seen in outpatient clinics or ER with symptoms that did not justify hospitalization.
  • Other: Measure of physiologic parameters
    Participants will have hepatic muscle and adipose tissue insulin sensitivity tested
COVID-19 negative Group COVID-19 negative (by PCR) and seen in outpatient clinics or ER during same time period as Groups I and II.
  • Other: Measure of physiologic parameters
    Participants will have hepatic muscle and adipose tissue insulin sensitivity tested

Recruiting Locations

Texas Diabetes Institute - University Health System
San Antonio, Texas 78207
Contact:
Andrea Hansis-Diarte, MPh
210-567-6691
hansisdiarte@uthscsa.edu

More Details

NCT ID
NCT05867017
Status
Recruiting
Sponsor
The University of Texas Health Science Center at San Antonio

Study Contact

Marzieh Salehi, MD
(210) 567-6691
salehi@uthscsa.edu

Detailed Description

The purpose of this research study is to understand the long-term effects of COVID-19 infection on individuals without any prior history of diabetes. This study will look at several measures of diabetes, such as glycemic control (blood glucose/sugar levels), function of beta cells (cells that make insulin to control sugar), insulin secretion and insulin sensitivity (fasting insulin levels). The following participants will be enrolled: 1) have had COVID-19 infection and were hospitalized and recovered, or 2) have had mild COVID-19 infection and were seen at outpatient clinics or ER and were not required to be hospitalized, or 3) have not had COVID-19 infection but were seen in outpatient clinics or ER during the same time period. The researchers hope to learn the long-term effects of COVID-19 infection in hospitalized patients. Specifically, they will be focusing on the subsequent development of diabetes and associated metabolic disturbances, such as impaired insulin secretion and insulin resistance. A relationship between COVID-19 and diabetes needs to be investigated.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.