Long-Term Sequelae of SARS-COV-2 Infection: Diabetes Mellitus
Purpose
Hospitalized patients with severe COVID-19 have an increased incidence of insulin resistance, impaired beta cell function, glucose intolerance (prediabetes), and overt type 2 diabetes (T2D) compared to non-hospitalized patients with COVID-19 and COVID-19 negative individuals on long-term follow up.
Conditions
- COVID-19
- Diabete Mellitus
Eligibility
- Eligible Ages
- Between 18 Years and 75 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Body Mass index (BMI) < 40 kg/m2
Exclusion Criteria
- History of diabetes prior to SARS-CoV-2 infection - Took medications used to treat diabetes prior to SARS-CoV-2 infection - History of myocardial infarction or stroke within 6 months - History of major organ system disease prior to COVID-19 infection
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Other
Arm Groups
Arm | Description | Assigned Intervention |
---|---|---|
Severe COVID-19 Group | Hospitalized in ICU with COVID-19 (PCR positive) and recovered |
|
Mild COVID-19 positive Group | COVID-19 positive (by PCR) who recovered from mild COVID-19 and were seen in outpatient clinics or ER with symptoms that did not justify hospitalization. |
|
COVID-19 negative Group | COVID-19 negative (by PCR) and seen in outpatient clinics or ER during same time period as Groups I and II. |
|
Recruiting Locations
San Antonio, Texas 78207
More Details
- NCT ID
- NCT05867017
- Status
- Recruiting
- Sponsor
- The University of Texas Health Science Center at San Antonio
Detailed Description
The purpose of this research study is to understand the long-term effects of COVID-19 infection on individuals without any prior history of diabetes. This study will look at several measures of diabetes, such as glycemic control (blood glucose/sugar levels), function of beta cells (cells that make insulin to control sugar), insulin secretion and insulin sensitivity (fasting insulin levels). The following participants will be enrolled: 1) have had COVID-19 infection and were hospitalized and recovered, or 2) have had mild COVID-19 infection and were seen at outpatient clinics or ER and were not required to be hospitalized, or 3) have not had COVID-19 infection but were seen in outpatient clinics or ER during the same time period. The researchers hope to learn the long-term effects of COVID-19 infection in hospitalized patients. Specifically, they will be focusing on the subsequent development of diabetes and associated metabolic disturbances, such as impaired insulin secretion and insulin resistance. A relationship between COVID-19 and diabetes needs to be investigated.