Purpose

The purpose of this study is to test if senescent cells and their secretome contribute to Long-Hauler Syndrome and if a clinical trial of senolytic drugs, which selectively eliminate senescent cells, should be initiated.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Ability to give informed consent or LAR. - At least 18 years old. - Ability of subject or LAR to read and speak the English language. - Positive PCR or antibody test within 12 months of initial study visit. - Patient of the Long-Hauler Syndrome clinic and differential diagnosis of Long-Hauler Syndrome.

Exclusion Criteria

  • Any potential participant who refuses medical record review. - Pregnant females. - Incarcerated individuals. - Inability to cooperate or any medical condition that, in the opinion of the investigator, interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study. Control Cohort - Inclusion Criteria: - Ability to give informed consent - At least 18 years old - Ability of subject to read and speak the English language Exclusion Criteria: - Known case of COVID-19. - Any potential participant who refuses medical record review. - Pregnant females. - Incarcerated individuals. - Inability to cooperate or any medical condition that interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study. COVID-19 Control Cohort Inclusion Criteria: - Ability to give informed consent. - At least 18 years old. - Ability of subject to read and speak the English language. - Known case of COVID-19. Exclusion Criteria: - Known Longhauler's syndrome/Post-COVID - Any potential participant who refuses medical record review. - Pregnant females. - Incarcerated individuals. - Inability to cooperate or any medical condition that interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study.

Study Design

Phase
Study Type
Observational
Observational Model
Case-Only
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Longhauler's Syndrome Cohort Subject's with longhaulers
Control Cohort Control cohort will not have had a known case of COVID-19 or Longhauler's syndrome
COVID Control Cohort Subjects who have had COVID-19 but no known Longhauler's syndrome

Recruiting Locations

More Details

NCT ID
NCT04903132
Status
Enrolling by invitation
Sponsor
Mayo Clinic

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.