Cellular Senescence and COVID-19 Long-Hauler Syndrome
Purpose
The purpose of this study is to test if senescent cells and their secretome contribute to Long-Hauler Syndrome and if a clinical trial of senolytic drugs, which selectively eliminate senescent cells, should be initiated.
Condition
- SARS-CoV2 Infection
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Ability to give informed consent or LAR. - At least 18 years old. - Ability of subject or LAR to read and speak the English language. - Positive PCR or antibody test within 12 months of initial study visit. - Patient of the Long-Hauler Syndrome clinic and differential diagnosis of Long-Hauler Syndrome.
Exclusion Criteria
- Any potential participant who refuses medical record review. - Pregnant females. - Incarcerated individuals. - Inability to cooperate or any medical condition that, in the opinion of the investigator, interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study. Control Cohort - Inclusion Criteria: - Ability to give informed consent - At least 18 years old - Ability of subject to read and speak the English language Exclusion Criteria: - Known case of COVID-19. - Any potential participant who refuses medical record review. - Pregnant females. - Incarcerated individuals. - Inability to cooperate or any medical condition that interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study. COVID-19 Control Cohort Inclusion Criteria: - Ability to give informed consent. - At least 18 years old. - Ability of subject to read and speak the English language. - Known case of COVID-19. Exclusion Criteria: - Known Longhauler's syndrome/Post-COVID - Any potential participant who refuses medical record review. - Pregnant females. - Incarcerated individuals. - Inability to cooperate or any medical condition that interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study.
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Case-Only
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Longhauler's Syndrome Cohort | Subject's with longhaulers | |
| Control Cohort | Control cohort will not have had a known case of COVID-19 or Longhauler's syndrome | |
| COVID Control Cohort | Subjects who have had COVID-19 but no known Longhauler's syndrome |
Recruiting Locations
More Details
- NCT ID
- NCT04903132
- Status
- Enrolling by invitation
- Sponsor
- Mayo Clinic