Search Clinical Trials
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Prospective Clinical Evaluation of COVID/Flu Detect™ Rapid Self-Test in Symptomatic Subjects for No1
InBios International, Inc.
COVID-19
Influenza a
Influenza B
The goal of this study is to evaluate the performance of the COVID/Flu Detect™ Rapid
Self-Test when used in a home-like setting by lay users. The COVID/Flu Detect™ Rapid
Self-Test is an investigational device intended for the qualitative detection and
differentiation of SARS-CoV-2, influenza A, and1 expand
The goal of this study is to evaluate the performance of the COVID/Flu Detect™ Rapid Self-Test when used in a home-like setting by lay users. The COVID/Flu Detect™ Rapid Self-Test is an investigational device intended for the qualitative detection and differentiation of SARS-CoV-2, influenza A, and influenza B protein antigens in nasal swab samples. Participants who are aged two (2) years and older and have symptoms of respiratory illness consistent with SARS-CoV-2 and influenza infection may be enrolled. Participants will use the COVID/Flu Detect™ Rapid Self-Test to self-collect, self-test, and interpret the results. Participants will have a nasal swab sample collected by a healthcare provider for comparator testing by PCR tests for SARS-CoV-2, influenza A, and influenza B. Researchers will compare the results of the COVID/Flu Detect™ Rapid Self-Test obtained by the participants to results from the PCR comparator tests to evaluate performance. Type: Observational Start Date: Dec 2024 |
Aviptidil for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)
National Institute of Allergy and Infectious Diseases (NIAID)
Covid19
This study looks at the safety and effectiveness of Aviptidil in treating COVID-19 in
people who have been hospitalized with the infection and who have acute respiratory
failure. Participants in the study will be treated with Aviptidil plus current standard
of care (SOC), or with placebo plus curre1 expand
This study looks at the safety and effectiveness of Aviptidil in treating COVID-19 in people who have been hospitalized with the infection and who have acute respiratory failure. Participants in the study will be treated with Aviptidil plus current standard of care (SOC), or with placebo plus current SOC. Type: Interventional Start Date: Apr 2021 |
A Pilot RTMS Trial for Neuropsychiatric Symptoms of Long-COVID
University of California, Los Angeles
Long Covid-19
PASC Post Acute Sequelae of COVID 19
Brain Fog
Fatigue
This is a pilot randomized trial of rTMS for symptoms of fatigue and brain fog, and other
neuropsychiatric symptoms of Long-COVID (Post-COVID, post-acute sequelae of COVID-19
infection, PASC). Twenty participants diagnosed with Long-COVID and recruited from the
UCLA Long-COVID clinic will be random1 expand
This is a pilot randomized trial of rTMS for symptoms of fatigue and brain fog, and other neuropsychiatric symptoms of Long-COVID (Post-COVID, post-acute sequelae of COVID-19 infection, PASC). Twenty participants diagnosed with Long-COVID and recruited from the UCLA Long-COVID clinic will be randomized to receive active rTMS versus sham stimulation for 15 treatments followed by another 15 open-label rTMS treatments. Investigators will compare the safety and tolerability of rTMS vs Sham and examine within-group changes in symptoms of fatigue, sleep, pain, mood, and subjective and objective cognitive impairment. This project will provide information and pilot data for future larger clinical trials. Type: Interventional Start Date: Jan 2025 |
SARS-CoV-2 and Influenza A/B in Point-of-Care and Non-Laboratory Settings
Aptitude Medical Systems
SARS-CoV-2 Infection
Influenza a
Influenza B
The Metrix COVID/Flu Test will be evaluated for use in Point-of-Care and Non-Laboratory
settings in a home testing environment utilizing the clinical study design described
herein. The study will take place in simulated home environments which will be set up
within or near active clinical settings1 expand
The Metrix COVID/Flu Test will be evaluated for use in Point-of-Care and Non-Laboratory settings in a home testing environment utilizing the clinical study design described herein. The study will take place in simulated home environments which will be set up within or near active clinical settings (e.g., urgent care facilities). This will be a prospective study conducted at three or more investigational sites located within the United States for the clinical validation of the Metrix COVID/Flu Test for the differential detection of SARS-CoV-2, Influenza A, and Influenza B in AN swab or saliva samples. Additional sites may be added to the study in order to meet minimum subject/sample enrollment requirements and geographic prevalence of respiratory virus infections. One or more investigational sites outside of the US (at which participants are required to be fluent in English) may also be included in the study depending on enrollment needs and geographical/seasonal prevalence of respiratory virus infections. Comparator testing will be performed to determine the infection status of each sample for comparison to results generated by the candidate test. The primary comparator for the study will be an FDA-cleared assay for the detection of SARS-CoV-2, Flu A, and/or Flu B. Type: Interventional Start Date: Nov 2023 |
Brief Digital Intervention to Increase COVID-19 Vaccination Among Individuals With Anxiety or Depre1
City University of New York, School of Public Health
Misinformation
Vaccine Hesitancy
Anxiety
Depression
COVID-19
The COVID-19 pandemic has led to a mis/disinformation ecosystem that promotes divergent
views of vaccine efficacy, as well as the legitimacy of science and medicine. Individuals
are confronted with vaccine-related information from a multitude of sources, posing a
challenge to identifying inaccurate1 expand
The COVID-19 pandemic has led to a mis/disinformation ecosystem that promotes divergent views of vaccine efficacy, as well as the legitimacy of science and medicine. Individuals are confronted with vaccine-related information from a multitude of sources, posing a challenge to identifying inaccurate information. COVID-19 vaccine uptake is lower among people with anxiety and depression than in the general population, due in part to higher levels of vaccine hesitancy. The prevalence of anxiety and depressive symptoms among US adults increased significantly during the COVID pandemic and has remained elevated. Interventions capable of mitigating the impact of vaccine hesitancy and mis/disinformation among undervaccinated people with anxiety or depression are therefore an urgent priority. Emerging evidence suggests that reasons for vaccine hesitancy and the impact of conventional vaccination messaging differ between those with and without mental health symptoms. There may also be added challenges overcoming logistical barriers to vaccination for people with anxiety or depressive symptoms. The investigators aim to determine the effectiveness of two different brief digital intervention strategies compared with conventional public health messaging for increasing vaccine uptake in undervaccinated adults with and without anxiety or depressive symptoms. Attitudinal inoculation is a brief, scalable strategy that leverages the power of narrative, values, and emotion to strengthen resistance to mis/disinformation and reduce hesitancy. Though this approach has been shown to decrease COVID-19 vaccine hesitancy among US adults, the extent to which this approach increases COVID-19 vaccination remains unknown. Cognitive-behavioral therapy (CBT) is an evidence-based intervention for anxiety and depression. However, the efficacy of incorporating CBT-informed messaging in a vaccine promotion intervention has not been tested. The investigators hypothesize that both attitudinal inoculation and CBT-style communication will be more effective than conventional public health messaging to increase COVID-19 vaccination. The investigators also hypothesize that the CBT-informed intervention will be more effective than the attitudinal inoculation intervention for increasing COVID-19 vaccination among participants with symptoms of anxiety or depression. Type: Interventional Start Date: Apr 2024 |
Phase 3 Adolescent Study for SARS-CoV-2 rS Variant Vaccines
Novavax
COVID-19
This study is a large-scale investigation (Phase 3) into a new booster shot designed
specifically for teenagers. The booster targets a particular variant of COVID-19, Omicron
XBB.1.5. The main focus is on safety: researchers want to see if this new booster is safe
for teenagers who have already rec1 expand
This study is a large-scale investigation (Phase 3) into a new booster shot designed specifically for teenagers. The booster targets a particular variant of COVID-19, Omicron XBB.1.5. The main focus is on safety: researchers want to see if this new booster is safe for teenagers who have already received two doses of the Pfizer or Moderna mRNA COVID-19 vaccines. To ensure a fair comparison, the study will use a double-blind approach. This means two groups of teenagers will receive booster shots, but neither the teenagers nor the researchers giving the shots will know beforehand which version of the booster each person gets. The study will also assess how well the body fights the virus after the booster shot. Type: Interventional Start Date: Aug 2023 |
Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE): Shionogi Proteas1
University of Minnesota
COVID-19
Treatments are needed to improve outcomes among patients hospitalized for COVID-19,
including direct-acting antiviral (DAA) agents to mitigate the pathology driven by
ongoing viral replication. This trial will evaluate S-217622 (ensitrelvir), an
anti-SARS-CoV2 3C-like protease inhibitor (PI) develo1 expand
Treatments are needed to improve outcomes among patients hospitalized for COVID-19, including direct-acting antiviral (DAA) agents to mitigate the pathology driven by ongoing viral replication. This trial will evaluate S-217622 (ensitrelvir), an anti-SARS-CoV2 3C-like protease inhibitor (PI) developed by Shionogi &; Co. Ltd. The study design is a randomized, placebo-controlled, multi-center international clinical trial that will evaluate the clinical efficacy of ensitrelvir when given in addition to standard of care (SOC) for inpatients with COVID-19. The SOC will be determined by local established guidelines and may include additional DAA (e.g., remdesivir) and immunomodulatory treatment strategies. Certain SOC treatments will be pre-specified prior to randomization. Type: Interventional Start Date: Dec 2022 |
Crowdsourcing an Open COVID-19 Imaging Repository for AI Research
University of Central Florida
COVID-19
The objectives of this project are to (1) assemble a crowdsourced, de-identified
radiographic repository; and (2) train and validate existing COVID-NET deep learning
diagnostic models. expand
The objectives of this project are to (1) assemble a crowdsourced, de-identified radiographic repository; and (2) train and validate existing COVID-NET deep learning diagnostic models. Type: Observational [Patient Registry] Start Date: Nov 2020 |
Myocardial Injury and Dysfunction Associated With COVID-19 Vaccination
University of Colorado, Denver
Myocardial Injury
COVID-19
Vaccine Reaction
The overall goal of the study is to investigate the characteristics and potential
mechanisms responsible for myocardial injury and dysfunction in patients after COVID-19
vaccination. Cardiac damage will be assessed with cardiac MRI and endomyocardial biopsy
(EmBx) histopathology. Myocardial gene ex1 expand
The overall goal of the study is to investigate the characteristics and potential mechanisms responsible for myocardial injury and dysfunction in patients after COVID-19 vaccination. Cardiac damage will be assessed with cardiac MRI and endomyocardial biopsy (EmBx) histopathology. Myocardial gene expression will be measured in RNA extracted from EmBxs mRNA abundance compared to nonfailing and failing control hearts. Type: Observational Start Date: May 2021 |
Evaluation of Immunologic Response Following COVID-19 Vaccination in Children, Adolescents, and You1
Children's Oncology Group
COVID-19 Infection
Hematopoietic and Lymphatic System Neoplasm
Malignant Solid Neoplasm
This study evaluates immunologic response following COVID-19 vaccination in children,
adolescents, and young adults with cancer. Vaccines work by stimulating the body's immune
cells to respond against a specific disease. The immune response produces protection from
that disease. Effects from cancer1 expand
This study evaluates immunologic response following COVID-19 vaccination in children, adolescents, and young adults with cancer. Vaccines work by stimulating the body's immune cells to respond against a specific disease. The immune response produces protection from that disease. Effects from cancer and from treatments for cancer can reduce the body's natural disease fighting ability (called immunity). Factors such as vaccine type, timing of vaccine dosing related to treatment for cancer and number of vaccine doses or "boosts" (extra vaccine shots) may strengthen or diminish the body's protective immune response. This study may help researchers learn more about how the body's immune system responds to the COVID-19 vaccine when the vaccination is given during or after cancer treatment. Type: Observational Start Date: Apr 2022 |
Efficacy and Safety of COVID-19 Vaccine in Cancer Patients
Mayo Clinic
COVID-19 Infection
Malignant Solid Neoplasm
This study gathers information about how a cancer patient responds to COVID-19 vaccine
during cancer treatment compared to healthy individuals. The information gained may help
determine how effective currently available COVID-19 vaccines are in cancer patients
receiving chemotherapy and learn more1 expand
This study gathers information about how a cancer patient responds to COVID-19 vaccine during cancer treatment compared to healthy individuals. The information gained may help determine how effective currently available COVID-19 vaccines are in cancer patients receiving chemotherapy and learn more regarding how long an immune response will last compared to healthy individuals. Type: Observational Start Date: Mar 2021 |
COVID-19 Survivorship Registry
NYU Langone Health
Covid19
COVID-19 is associated with acute pulmonary and cardiac injury. To better understand the
degree and severity of cardiopulmonary injury as well as short and long-term sequelae of
COVID-19 infection, this study will perform longitudinal study in patients who had recent
known diagnosis of COVID-19. expand
COVID-19 is associated with acute pulmonary and cardiac injury. To better understand the degree and severity of cardiopulmonary injury as well as short and long-term sequelae of COVID-19 infection, this study will perform longitudinal study in patients who had recent known diagnosis of COVID-19. Type: Observational [Patient Registry] Start Date: Jul 2020 |
A Clinical Observational Study of SARS-CoV-2 Specific CD8 T-Cell Responses to COVID-19 Vaccines in1
National Institute on Aging (NIA)
COVID-19
Background:
The immune response is how the body recognizes and defends itself against foreign and
harmful substances. Researchers want to compare the immune responses between young and
older healthy adults after they receive vaccine doses for COVID-19. This research may
help to determine whether a1 expand
Background: The immune response is how the body recognizes and defends itself against foreign and harmful substances. Researchers want to compare the immune responses between young and older healthy adults after they receive vaccine doses for COVID-19. This research may help to determine whether age impacts cell response to COVID-19 vaccines. Objective: To study the immune response of people who receive Pizer or Moderna COVID-19 vaccines. Eligibility: People aged 18 and older who have not had COVID-19 and who either plan to receive the first dose of a COVID-19 vaccine within the next month or have received at least the first of 2 doses of the vaccine within the last 6 months. Design: Participants will be screened by telephone. Participants will not get the COVID-19 vaccine in this study. They must get it through a vaccine location. Participants who have not yet been vaccinated will have 7 visits. The first 4 visits will occur in the first month before and after each vaccination. The last 3 visits will occur 6 months, 1 year, and 2 years after completed vaccination. Participants who have received at least 1 of 2 doses of the COVID-19 vaccine within the last 6 months will have 3 visits. The first visit will occur within 6 months of receiving the first vaccine dose. The last 2 visits will occur 1 year and 2 years after the first vaccine dose. At visits, participant will review their medical history. Their height, weight, and/or vital signs will be measured. They will give blood samples after fasting. They may give urine samples. They may have a nasal swab test for COVID-19. Type: Observational Start Date: Apr 2021 |
Identification and Characterization of SARS-CoV-2 Specific CD8 T Cells in Humans
National Institute on Aging (NIA)
COVID-19
Background:
The higher death rate from COVID-19 in the older population is associated with low CD8 T
cell counts in the blood. Researchers want to learn the status of CD8 T cells specific to
SARS-CoV-2 and their changes with aging and in COVID-19. This may help to identify why
COVID-19 is particul1 expand
Background: The higher death rate from COVID-19 in the older population is associated with low CD8 T cell counts in the blood. Researchers want to learn the status of CD8 T cells specific to SARS-CoV-2 and their changes with aging and in COVID-19. This may help to identify why COVID-19 is particularly lethal in the elderly and help to create an effective vaccine against SARS-CoV-2 in the elderly. Objective: To identify SARS-CoV-2 specific CD8 T cells in humans, and to determine their quantity and quality in people who have recovered from COVID-19. Eligibility: Maryland residents age 18 and older who have tested positive for and recovered from COVID-19. Design: Participants will be screened by phone. They must be able to provide a copy of their positive COVID-19 test result. Participants will visit the NIA/Clinical Research Unit. The visit will take about 1 hour. Laboratory tests showing a positive COVID-19 result will be verified. Participants vital signs will be checked. This will include blood pressure, temperature, pulse, and respiration. Height and weight will be measured. Participants will have a medical history and medicine review. They will complete a COVID-19 questionnaire. Participants will have blood drawn. They will give a urine sample. Participants will give a saliva sample. They will rinse their mouth with water. After about 3 minutes, they will let saliva pool in the base of their mouth and then spit into a sterile container. Participants may be asked if they would be willing to return for optional visits at about 4 months and 1 year later. They will repeat the same laboratory sampling performed at the first visit. ... Type: Observational Start Date: Sep 2020 |
Investigation of the B- and T-cell Repertoire and Immune Response in Patients With Acute and Resolv1
National Cancer Institute (NCI)
COVID-19
Background:
People who get infected with COVID-19 have an unpredictable risk to worsen and die. This
makes it hard to decide who can quarantine at home and who should be treated at a
hospital. Researchers think the risk may be related to how a person s B and T cells
respond to the virus. B and T c1 expand
Background: People who get infected with COVID-19 have an unpredictable risk to worsen and die. This makes it hard to decide who can quarantine at home and who should be treated at a hospital. Researchers think the risk may be related to how a person s B and T cells respond to the virus. B and T cells are the major components of a person s immune response. B and T cells responding to the virus with a favorable pattern may lead to recovery, and this favorable pattern may be helpful to establish. If people in a vaccine trial get this same favorable pattern when responding to a vaccine, this may be a useful early signal that the vaccine will be successful. Objective: To examine how immune cells respond to COVID-19 infection. Eligibility: Adults ages 18 and older who have a confirmed or suspected COVID-19 infection or had COVID-19 in the past. Also, healthy donors with no suspected COVID-19 infection Design: Participants will be screened with medical record review. Participants will be tested with a research assay to determine who was infected with COVID-19 and who was not. This test will be used to understand research results, not to advise patients. Participants with active infection must be isolated, usually in a hospital. Other participants may give blood samples at NIH or at their local doctor s office or lab. Participants may give blood samples up to three times a week for a total of ten times, and may also give blood samples after starting a vaccine trial. Participants will be contacted by phone or email every 2 months for up to 2 years. Type: Observational Start Date: Apr 2020 |
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ALG-097558 in Subjects with Re1
Aligos Therapeutics
COVID 19
This is a Phase 1 non-randomized, open-label, multiple dose, parallel-group study of
ALG-097558 in subjects with severe renal impairment and subjects without renal
impairment, matched for age, body weight and, to the extent possible, for gender. The
primary purpose of this study is to characterize1 expand
This is a Phase 1 non-randomized, open-label, multiple dose, parallel-group study of ALG-097558 in subjects with severe renal impairment and subjects without renal impairment, matched for age, body weight and, to the extent possible, for gender. The primary purpose of this study is to characterize the effect of renal impairment on the plasma pharmacokinetics of ALG-097558 following administration of multiple, twice daily (Q12H) oral (PO) doses. Type: Interventional Start Date: Jan 2025 |
A Study to Learn About Flu and COVID-19 Vaccine Responses in Healthy People
BioNTech SE
Influenza,Human
COVID-19
This study is to learn about flu and COVID vaccines, either alone or when mixed together.
Healthy people aged 18 or older can join. Participants will get one shot in each arm,
either a flu or COVID vaccine, alone or mixed. The study lasts about 6 months, and
participants need to visit the research1 expand
This study is to learn about flu and COVID vaccines, either alone or when mixed together. Healthy people aged 18 or older can join. Participants will get one shot in each arm, either a flu or COVID vaccine, alone or mixed. The study lasts about 6 months, and participants need to visit the research site at least 3 times. Type: Interventional Start Date: Nov 2024 |
Synbiotic Therapy for NP-PASC
Columbia University
Post-Acute COVID-19 Syndrome
Long COVID-19
Gut microbiome dysbiosis has been noted in patients with Post-acute sequelae (PASC) of
Severe Acute Respiratory Syndrome-CoronaVirus -2 (SARS-CoV-2). A study performed at
Columbia found that plasma levels of the short chain fatty acid (SCFA), butyric acid,
remained lower in people with Neuropsychia1 expand
Gut microbiome dysbiosis has been noted in patients with Post-acute sequelae (PASC) of Severe Acute Respiratory Syndrome-CoronaVirus -2 (SARS-CoV-2). A study performed at Columbia found that plasma levels of the short chain fatty acid (SCFA), butyric acid, remained lower in people with Neuropsychiatric PASC (NP-PASC) than in people with PASC after SAR-CoV-2 infection. Synbiotics improve SCFA levels and are well-tolerated in the general population but have not been studied among people with PASC in the United States. The purpose of this pilot study is to characterize changes in plasma SCFA levels and gut microbiome after treatment with synbiotics and placebo in people with NP-PASC. The intervention will be a mixture of the prebiotic resistant starch and the probiotic Bifidobacterium adolescentis in-vivo selection 1 strain (iVS-1). The placebo will be Maltodextrin. Type: Interventional Start Date: Nov 2024 |
Antiviral Clinical Trial for Long Covid-19
Icahn School of Medicine at Mount Sinai
Long Covid
The trial will test if two repurposed HIV antivirals can reduce symptom burden in adult
participants with Long Covid compared to placebo. Viral infection and viral reactivation
have been documented in Long Covid.
Participants will be randomly allocated to receive antivirals, Truvada (tenofovir
dis1 expand
The trial will test if two repurposed HIV antivirals can reduce symptom burden in adult participants with Long Covid compared to placebo. Viral infection and viral reactivation have been documented in Long Covid. Participants will be randomly allocated to receive antivirals, Truvada (tenofovir disoproxil/emtricitabine, TDF/FTC, Group 1) or Selzentry (Group 2), or a placebo (pill) (Group 3), taken daily for 90 days. Type: Interventional Start Date: Oct 2024 |
A Study to Learn About Two or More Vaccines That Are Put Together as One Shot Against Infectious Lu1
Pfizer
Healthy Participants
The purpose of the study is to learn about the safety and effects of a combined vaccine
for RSV and COVID-19 when given with a seasonal flu vaccine or when given alone. A
combined vaccine will help to reduce the number of vaccinations given when trying to
prevent respiratory infections.
This study1 expand
The purpose of the study is to learn about the safety and effects of a combined vaccine for RSV and COVID-19 when given with a seasonal flu vaccine or when given alone. A combined vaccine will help to reduce the number of vaccinations given when trying to prevent respiratory infections. This study is seeking participants who: - are 65 years of age or older. - are healthy or have well-controlled chronic conditions. - in the past have received at least 3 US-authorized mRNA COVID 19 vaccines, with the most recent vaccine being an updated booster vaccine given at least more than or equal to 150 days before Visit A101 (Day 1). - have not had a flu shot in the last 120 days. - agree to be present for all study visits, procedures, and blood draws. Participants will be involved in this study for 6 months. During this time, participants will have 2 study visits at the study clinic and a 6-month telephone contact. Type: Interventional Start Date: Jun 2023 |
Qigong for Post Acute Sequelae of COVID-19 Infection
University of California, Davis
Long COVID
The purpose of this study is to conduct a pilot feasibility study of external qigong on
health-related quality of life in individuals with prolonged symptoms following COVID-19
infection. expand
The purpose of this study is to conduct a pilot feasibility study of external qigong on health-related quality of life in individuals with prolonged symptoms following COVID-19 infection. Type: Interventional Start Date: Jan 2023 |
eVusheld Assessment reaL wORld Effectiveness at UPMC
AstraZeneca
SARS-CoV-2, COVID-19
An AstraZeneca-sponsored observational, electronic healthcare record (EHR)-embedded
retrospective cohort study to assess the real-world effectiveness of EVUSHELD against
SARS-CoV-2 infection, COVID-19-related hospitalization, and other COVID-19 related
outcomes in the total EUA-eligible patient pop1 expand
An AstraZeneca-sponsored observational, electronic healthcare record (EHR)-embedded retrospective cohort study to assess the real-world effectiveness of EVUSHELD against SARS-CoV-2 infection, COVID-19-related hospitalization, and other COVID-19 related outcomes in the total EUA-eligible patient population in the University of Pittsburgh Medical Center (UPMC) Health System. Type: Observational Start Date: Jan 2023 |
VNS for Long-COVID-19
Icahn School of Medicine at Mount Sinai
Post-COVID-19 Syndrome
Postural Tachycardia Syndrome
Dysautonomia
The goal of this proposed clinical case series is to evaluate the effect of a
non-invasive vagus nerve stimulation paradigm on: 1) Symptom reporting via validated
patient reported outcomes, and 2) objective clinical biomarkers of autonomic nervous
system function.
This will be a placebo controlled1 expand
The goal of this proposed clinical case series is to evaluate the effect of a non-invasive vagus nerve stimulation paradigm on: 1) Symptom reporting via validated patient reported outcomes, and 2) objective clinical biomarkers of autonomic nervous system function. This will be a placebo controlled, randomized controlled trial with a crossover design built in. This study will aim to recruit 40 people with Long COVID to be a part of this research. Type: Interventional Start Date: Nov 2022 |
VAX-MOM COVID-19: Increasing Maternal COVID-19 Vaccination
University of Rochester
Immunization; Infection
Pregnancy Related
COVID-19
COVID-19 infection during pregnancy is associated with increased risk of pre-eclampsia,
preterm birth and stillbirth. Pregnant people with COVID-19 have a higher rate of ICU
admission and intubation than those who are not pregnant. COVID-19 vaccine is recommended
before pregnancy and during pregnan1 expand
COVID-19 infection during pregnancy is associated with increased risk of pre-eclampsia, preterm birth and stillbirth. Pregnant people with COVID-19 have a higher rate of ICU admission and intubation than those who are not pregnant. COVID-19 vaccine is recommended before pregnancy and during pregnancy to decrease these risks. Despite the benefits of COVID-19 vaccination, only 71% of pregnant women were vaccinated for COVID-19 as of June 2022 (most prior to pregnancy), with a much lower rate of 58% among non-Hispanic Black women. An effective intervention is needed to improve COVID vaccination rates for pregnant people overall. In this study, the investigators will perform a randomized controlled trial aimed at practice change in obstetricians' offices, with an overall goal of increasing maternal COVID-19 vaccination rates. Type: Interventional Start Date: Oct 2022 |
Psychological Well-being and Burnout in Healthcare Workers During the COVID-19 (Coronavirus Disease1
Northwestern University
COVID-19
Burnout
Burnout, Professional
Work-related Illness
Work-Related Stress
Healthcare systems around the world have faced tremendous stress because of the COVID-19
pandemic. Healthcare workers (HCWs) (ie. physicians, nurses, and support staff), who
serve as the foundation of the healthcare system, report high levels of psychological
stress and burnout, which will likely w1 expand
Healthcare systems around the world have faced tremendous stress because of the COVID-19 pandemic. Healthcare workers (HCWs) (ie. physicians, nurses, and support staff), who serve as the foundation of the healthcare system, report high levels of psychological stress and burnout, which will likely worsen as the pandemic continues. The consequences of stress and burnout can reduce quality of life for providers and lead to adverse health behaviors (poor dietary choices, reduced physical activity, increased alcohol intake, increases in weight etc.) among HCWs. In addition, burnout can have dire consequences on healthcare delivery effectiveness including poor quality of care and significant cost implications due to medical errors and HCW absenteeism and turnover. In fact, annual estimates of burn-out related turnover range from $7,600 per physician to >$16,000 per nurse. However, programs focused on reducing burnout in HCWs have the potential to reduce costs to the healthcare system by $5,000 per HCW per year. Maintaining and recovering psychological and behavioral well-being is essential to ensuring we have a workforce that is resilient to acute and ongoing stressors such as the COVID-19 pandemic, ensuring that they are capable of providing the highest level of quality and compassionate care to patients. In this project, we will strengthen the resiliency of the Northwestern Medicine (NM) healthcare system by implementing an online psychological well-being intervention (PARK). We will assess HCW willingness to engage in PARK, which has been shown in other populations experiencing stress (e.g. dementia caregivers, general public coping with COVID-19) to be effective. We will also assess if the PARK is effective in reducing stress and associated-burnout, absenteeism, and intentions to leave the workforce in a subset of 750 persons who have been participating in a study of HCWs at NM since Spring 2020. In the entire cohort, we will measure the psychological well-being, levels of burnout, health behaviors, absenteeism, and plans to leave the workforce at three time periods: the start, middle, and end of the study period and assess whether they differ by HCW characteristics including gender, race, and role in health care. Results from this study will provide much-needed information: 1) about the current state of psychological well-being and burnout among NM HCWs, now over 1 ½ years into the pandemic; 2) on the role of an online wellness intervention to improve well-being during a protracted pandemic; and 3) about the contribution of PARK to reduce burnout, HCW absenteeism and turnover, and potential impacts on costs. PARK has the potential to have a significant impact on not only NM HCWs but also to be generalizable to other healthcare organizations for addressing burnout and to contribute to lessons learned on how to support HCWs responding to future pandemics; ensuring resiliency in the healthcare delivery system. In addition, we will work with our already engaged stakeholder committee to ensure results can provide actionable policy and fiscal insights. Future opportunities will include collaboration with other healthcare systems to expand roll-out of the successful PARK intervention. Type: Interventional Start Date: Dec 2021 |
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