Ventilatory and Perfusion Abnormalities in Individuals with Post-Acute Sequelae of SARS-CoV-2 Infection
Purpose
Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations
Conditions
- Post-Acute COVID-19
- Post COVID-19 Condition
- Post Viral Fatigue
- Dyspnea
Eligibility
- Eligible Ages
- Between 18 Years and 99 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Age ≥ 18 - Self-reported or documented SARS-CoV-2 infection by RT-PCR or Antigen testing > 3 months ago or no previous history of SARS-CoV-2 infection (control group only) - Normal or mild abnormalities on baseline Pulmonary Function Tests (PFTs) - New or worsening symptoms of chronic fatigue, dyspnea or exercise intolerance after COVID-19 with otherwise unclear etiology (PASC group only)
Exclusion Criteria
- SARS-CoV-2 infection by RT-PCR or Antigen testing within the last 3 months - Inability to provide consent or non-English speaking - Pregnancy - Any respiratory infection in last 4 weeks - PFT relative contraindications - History of major cardiovascular, pulmonary, renal, hepatic, autoimmune or neuromuscular disease including asthma, COPD, interstitial lung disease, heart failure, pulmonary arterial hypertension, or prior pulmonary embolism - Active malignancy undergoing treatment or history of malignancy involving the lung
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Case-Control
- Time Perspective
- Cross-Sectional
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Post-Acute Sequelae of SARS-CoV-2 (PASC) Group | Subjects with PASC with a documented history of COVID-19 and persistent symptoms of fatigue, dyspnea, and/or exercise intolerance |
|
| Control: Fully recovered COVID-19 | Subjects with a history of COVID-19 who have fully recovered from COVID-19 with no post-acute sequelae of SARS-Cov-2 |
|
| Control: No history of COVID-19 | Healthy subjects without a documented history of COVID-19, no current symptoms, and a normal baseline High resolution CT of the chest |
|
Recruiting Locations
Tufts Medical Center
Boston, Massachusetts 02111
Boston, Massachusetts 02111
Contact:
Bipin Malla
Bipin Malla
More Details
- NCT ID
- NCT05866952
- Status
- Recruiting
- Sponsor
- Tufts Medical Center
Detailed Description
This is a study to describe the overall pattern of lung ventilation and perfusion defects in individuals with PASC. Subjects with PASC with a documented history of COVID-19 and persistent symptoms of fatigue, dyspnea, and/or exercise intolerance will complete questionnaires, and undergo pulmonary function tests, 6-minute walk tests, and a low dose CT chest to describe the overall pattern of lung regional ventilation and blood distribution and to compare this pattern to asymptomatic controls with and without prior COVID-19.