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Purpose

This study is being done to understand body's response to hybrid home-based and on-site rehabilitation program utilizing individually tailored exercises throughout a total of 18 sessions with 12 of them occurring onsite, in people with and without chronic respiratory diseases, such as Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) and in individuals recovered from COVID-19. Exercise training programs vary widely for people with COPD, OSA, and during prolonged recovery from COVID infection. This study will help identify if this program is helpful to address muscle loss and fatigue specifically in populations with and without chronic respiratory diseases.

Conditions

Eligibility

Eligible Ages
Between 30 Years and 85 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Ability to walk, sit down and stand up independently - Age 30 - 85 years - Ability to lay in supine or elevated position for up to 3 hours - Diagnosis of moderate to very severe chronic airflow limitation and compliant to the following criteria: FEV1 < 70% of reference FEV1 -or- Obstructive Sleep Apnea (OSA) -or- 2 weeks post-recovered* from laboratory confirmed case of COVID ● Willingness and ability to comply with the protocol *Recovered is defined according to Brazos County Health District as someone who has been fever-free for 24 hours without fever-reducing medications, and it has been 10 days after onset of symptoms. Inclusion criteria control subjects - Healthy male or female according to the investigator's or appointed staff's judgment - Ability to walk, sit down and stand up independently - Age 30 - 85 years - Ability to lay in supine or elevated position for up to 3 hours - No diagnosis of chronic lung disease - Willingness and ability to comply with the protocol

Exclusion Criteria

  • Unable to exercise due to physical limitations (i.e. neuromuscular and/or orthopedic disorders) - Established diagnosis of malignancy - Presence of acute illness or metabolically unstable chronic illness - Presence of fever within the last 3 days. - Expected to have surgery within 1 month of screening or during exercise training - Any other condition according to the PI or research staff that was found during the screening visit, that would interfere with the study or safety of the patient. - Previous injury that could interfere with participation in resistance exercise protocol. - Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements. - (Possible) pregnancy. - Already enrolled in another clinical trial and that clinical trial interferes with participating in this study. When during the period from enrollment to the test day any condition causing the subject to not meet inclusion criteria or to meet exclusion criteria, the subject will be excluded from the study.

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Recruiting Locations

Texas A&M University
College Station, Texas 77843
Contact:
Marielle P Engelen, Ph.D.
979-220-2282
mpkj.engelen@ctral.org

More Details

NCT ID
NCT05395390
Status
Unknown status
Sponsor
Texas A&M University

Study Contact

Marielle Engelen, PhD
9792202282
mpkj.engelen@ctral.org

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.