Recovery of Respiratory System in COVID-19 Patients
Purpose
The purpose of this study is to determine the effects of the clinical course of treatment as well as long-term symptoms of COVID-19 on respiratory function, exercise capacity, and quality of life.
Condition
- Covid19
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Have a documented positive qRT-PCR for SARS-CoV-2 confirming prior COVID-19 diagnosis - At least 18 years of age. - Female subjects must not be pregnant or trying to become pregnant during the duration of study participation. - No known plans to move out of the state, or become unable to return to one of the Mayo Clinic sites for follow-up testing. - Must be able to provide clear informed written consent.
Exclusion Criteria
- Individuals with pacemakers or other implantable devices that will make interpreting a CT scan challenging. - Individuals with major limitations to exercise.
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| COVID19 long haulers | Individuals that have been diagnosed with COVID19 and continue to have lingering symptoms associated with COVID19 | |
| COVID19 no residual symptoms | Individuals that have been diagnosed with COVID19 and do not have lingering symptoms that are associated with COVID19 |
Recruiting Locations
More Details
- NCT ID
- NCT04954222
- Status
- Completed
- Sponsor
- Mayo Clinic
Detailed Description
This study will be completed over 4 sessions at the Mayo Clinic at either the Scottsdale Arizona or Rochester Minnesota locations. You will be asked to complete a series of questionnaires, lung function tests, and exercise tests at two time points: ≥ 28 days post diagnosis and 4-6 months after the first laboratory visit. All visits will take approximately 2 hours. During visits 1 and 3 a series of questionnaires as well as breathing tests, and an exercise test will be completed on a stationary bike. You will also be asked to breathe a gas mixture out of a bag to obtain measures of gas movement and sensitivity. During visits 2 and 4 you will complete an exercise test on a stationary bike to measure changes from the previous exercise test and a chest scan.