Comparing the Effects of Different Doses of Dexamethasone to Treat Inpatient COVID-19
Purpose
This open label clinical trial is to evaluate two different doses of dexamethasone on the health outcome using World Health Organization ordinal scale at day 28 in hospitalized patients with COVID-19.
Condition
- Covid19
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Age ≥ 18 years old - RT-PCR confirmed COVID-19 infection - Positive pressure ventilation (non-invasive or invasive) or high flow nasal cannula (HFNC) or need supplemental oxygen with oxygen mask or nasal cannula
Exclusion Criteria
- Underlying disease requiring chronic corticosteroids - Severe adverse events before admission, i.e. cardiac arrest; - Contraindication for corticosteroids; - Death is deemed to be imminent and inevitable during the next 24 hours - Recruited in other clinical intervention trial - Pregnancy - Patient on judicial protection
Study Design
- Phase
- Phase 4
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
Arm | Description | Assigned Intervention |
---|---|---|
Experimental Dexamethasone 20 mg |
Dexamethasone 20 mg daily for 5 days, followed by dexamethasone 10 mg daily for 5 days |
|
Active Comparator Dexamethasone 6 mg |
Dexamethasone 6 mg daily for 10 days |
|
Recruiting Locations
More Details
- NCT ID
- NCT04707534
- Status
- Completed
- Sponsor
- University of Oklahoma
Detailed Description
The coronavirus disease 2019 (COVID-19) pandemic is a serious global health threat. Multiple antiviral or immunomodulatory therapies have failed to show any mortality benefit for patients with COVID-19. Dexamethasone was shown in prior studies to improve mortality and ventilator free days. However, it is unclear what dose of dexamethasone is most beneficial in hospitalized patients with COVID-19. This randomized single center open label clinical trial is to evaluate two different doses of dexamethasone (20mg vs. 6mg) on the health outcome for hospitalized patients with COVID-19. The intervention arm is dexamethasone 20mg daily for 5 days, followed by dexamethasone 10mg daily for 5 days. The comparator is dexamethasone 6mg daily for 10 days. Three hundred participants will be enrolled. The primary outcome is clinical improvement using World Health Organization ordinal scale at day 28.