Print

Purpose

There is a considerable variation in the disease behavior in terms of contracting the infection, manifesting none to a range of symptoms and severity of the infection among individuals exposed to or infected with SARS-CoV-2 virus, the causative organism of COVID-19. Although the respiratory system appears to be the primary target of this virus infection, emerging evidences suggests involvement of extra-pulmonary organs including central nervous system. We aim to compare the genetic profile of individuals with vs without COVID-19 after being exposed to infected cases. Additionally, we will assess the cognitive function in covid-19 positive cases with vs. without neurological symptoms at the time of infection and 1-month follow-up using the Montreal Cognitive Assessment (MoCA) questionnaire.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  1. Male or female over 18 years of age at the time of enrollment 2. Have symptoms of COVID-19 (with or without hospitalization) or contact history 3. Willing to undergo nasopharyngeal swab test for viral-RNA at baseline (in non-hospitalized cases) and the MoCA survey at baseline and 1-month follow-up

Exclusion Criteria

  1. Unwilling to provide informed consent 2. MoCA score ≤17 at baseline 3. Patients with clinical diagnosis of dementia 4. Impaired consciousness

Study Design

Phase
Study Type
Observational
Observational Model
Case-Only
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
COVID-19 positive
  • Genetic: Whole exome sequencing
    MoCA survey to evaluate cognitive function in COVID-19 positive cases with vs without neurological symptoms
    Other names:
    • Cognitive function
COVID-19 negative
  • Genetic: Whole exome sequencing
    MoCA survey to evaluate cognitive function in COVID-19 positive cases with vs without neurological symptoms
    Other names:
    • Cognitive function

Recruiting Locations

Texas Cardiac Arrhythmia Institute
Austin, Texas 78705
Contact:
Sanghamitra Mohanty
mitra1989@gmail.com

More Details

NCT ID
NCT04506229
Status
Unknown status
Sponsor
Texas Cardiac Arrhythmia Research Foundation

Study Contact

Sanghamitra Mohanty
5127842651
mitra1989@gmail.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.