A Clinical Study to Assess the Physiologic Effects of KB109 in Patients With COVID-19 on Gut Microbiota Structure and Function
Purpose
This exploratory, open-label clinical study aims to explore the physiologic effects of KB109, a novel glycan, on adult patients with COVID-19 illness on gut microbiota structure and function in the outpatient setting.
Condition
- Mild-to-Moderate COVID-19
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Be male or female, ≥18 years of age 2. Be willing and able to give informed consent 3. Screening/Randomization telemedicine visit within 2 days of testing positive test for COVID-19 4. Having self-reported fever or cough for not more than 72 hours prior to COVID-19 testing 5. Mild to moderate COVID-19 6. Able to adhere to the study visit schedule and other protocol requirements Patients who meet any of the following
Exclusion Criteria
at the Randomization Visit will not be enrolled into the study: 1. Patients who are hospitalized for in-patient treatment or currently being evaluated for potential hospitalization at the time of informed consent for conditions other than COVID-19 2. History of chronic lung disease 3. Ongoing requirement for oxygen therapy 4. Shortness of breath in resting position 5. Diagnosis of sleep apnea requiring Bilevel Positive Airway Pressure (BIPAP) / Continuous Positive Airway Pressure (CPAP) 6. Female patients who are pregnant, trying to become pregnant or lactating. 7. Is considered, in the opinion of the PI, to be unlikely for any reason to be able to comply with study procedures
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Other
- Masking
- None (Open Label)
Arm Groups
Arm | Description | Assigned Intervention |
---|---|---|
Other KB109 + Self Supportive Care (SSC) |
|
|
Other Self Supportive Care (SSC) Alone |
|
Recruiting Locations
More Details
- NCT ID
- NCT04486482
- Status
- Completed
- Sponsor
- Kaleido Biosciences