Detecting SARS-CoV-2 in Tears
Purpose
Purpose: - To determine the presence of SARS-CoV-2 in tears - To determine SARS-CoV-2 receptors in tear production system
Conditions
- COVID
- COVID-19
- Corona Virus Infection
- SARS-CoV-2
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Patients presenting at study sites with confirmed or suspected COVID-19
Exclusion Criteria
- Pregnancy or nursing - non-English speakers - Those unable to read - Those in other vulnerable study populations
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Case-Only
- Time Perspective
- Prospective
Arm Groups
Arm | Description | Assigned Intervention |
---|---|---|
COVID-19 Patients | All patients aged 18 years and above who present to Fairview/UMN ERs or ICUs with confirmed or suspect COVID-19 based on the attending physician's judgment will be included. |
|
Recruiting Locations
More Details
- NCT ID
- NCT04526769
- Status
- Completed
- Sponsor
- University of Minnesota
Detailed Description
This is a prospective case series. NP swab and tear samples will be collected simultaneously from the confirmed or suspected COVID-19 patients. The samples will be transferred to the lab for SARS-CoV-2 testing. The presence of absence of SARS-CoV-2 will be compared in tears versus NP swabs. The second part of the study is a histopathology examination series. Normal lacrimal gland and ocular surface tissue samples already stored at the UMN ocular pathology lab and Lion's Gift of Sight Eye Bank will be used for IHC staining for ACE2 and similar targets.