Search Clinical Trials
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Evaluation of the RD-X19 Treatment Device in Individuals With Mild COVID-19
EmitBio Inc.
COVID-19
This is a randomized, double-blind, sham controlled, stratified, pivotal efficacy and
safety study of the EmitBio RD-X19 treatment device in Individuals 40 Years of age and
older with Mild COVID-19 in the at-home setting. expand
This is a randomized, double-blind, sham controlled, stratified, pivotal efficacy and safety study of the EmitBio RD-X19 treatment device in Individuals 40 Years of age and older with Mild COVID-19 in the at-home setting. Type: Interventional Start Date: Apr 2023 |
AZD7442 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19
This study looks at the safety and effectiveness of AZD7442 in treating COVID-19 in
people who have been hospitalized with the infection. Participants in the study will be
treated with either a AZD7442 plus current standard of care (SOC), or with placebo plus
current SOC. This is ACTIV-3/TICO Treatment... expand
This study looks at the safety and effectiveness of AZD7442 in treating COVID-19 in people who have been hospitalized with the infection. Participants in the study will be treated with either a AZD7442 plus current standard of care (SOC), or with placebo plus current SOC. This is ACTIV-3/TICO Treatment Trial H4. Type: Interventional Start Date: Feb 2021 |
VNS for Long-COVID-19
Icahn School of Medicine at Mount Sinai
Post-COVID-19 Syndrome
Postural Tachycardia Syndrome
Dysautonomia
The goal of this proposed clinical case series is to evaluate the effect of a
non-invasive vagus nerve stimulation paradigm on: 1) Symptom reporting via validated
patient reported outcomes, and 2) objective clinical biomarkers of autonomic nervous
system function.
This will be a placebo controlled,... expand
The goal of this proposed clinical case series is to evaluate the effect of a non-invasive vagus nerve stimulation paradigm on: 1) Symptom reporting via validated patient reported outcomes, and 2) objective clinical biomarkers of autonomic nervous system function. This will be a placebo controlled, randomized controlled trial with a crossover design built in. This study will aim to recruit 40 people with Long COVID to be a part of this research. Type: Interventional Start Date: Nov 2022 |
COVID-19 Screening Program
University of Pennsylvania
COVID-19
In view of the recent COVID surge and difficulties in obtaining testing, we aim to
increase Point of Care (POC) testing, whereby University of Pennsylvania (Penn) faculty,
staff, and trainees who are working in person at Perelman School of Medicine (PSOM)
laboratories can self-test. The purpose of... expand
In view of the recent COVID surge and difficulties in obtaining testing, we aim to increase Point of Care (POC) testing, whereby University of Pennsylvania (Penn) faculty, staff, and trainees who are working in person at Perelman School of Medicine (PSOM) laboratories can self-test. The purpose of this study is to evaluate the implementation of this POC testing program. We will not be collecting any samples as part of this study. This will ensure that individuals can rapidly identify if they have COVID-19 while balancing use, acceptability, appropriateness, and feasibility. We will start with a pilot phase whereby we will evaluate the implementation of a POC version of COVID-19 screening program that will coordinate several existing systems at the University of Pennsylvania including voluntary, self-administered saliva-based viral testing. We will pilot this program to a small cohort of PSOM labs and then test implementation of the self-testing of the POC version of COVID-19 screening across all PSOM labs for those who wish to participate. All results will be self-reported and will not be used to validate any tests or support any future approval from the FDA. No data from this study will go into the participants' Electronic Medical Record (EMR). Type: Observational Start Date: Feb 2022 |
Mindfulness Intervention for Post-Covid Symptoms
Mayo Clinic
COVID-19
Post Acute Sequelae of SARS-CoV-2
The purpose of this research is to study if post-Covid patients using a wearable brain
sensing wellness device (Muse-S) to learn meditation practice during a time where they
are experiencing lengthy Covid symptoms will help in decreasing stress and anxiety. expand
The purpose of this research is to study if post-Covid patients using a wearable brain sensing wellness device (Muse-S) to learn meditation practice during a time where they are experiencing lengthy Covid symptoms will help in decreasing stress and anxiety. Type: Interventional Start Date: Jun 2022 |
COVID-19: Healthy Oregon (Oregon Saludable): Together We Can (Juntos Podemos) Phase II
University of Oregon
Health Behavior
Health Care Utilization
The global SARS-CoV-2 pandemic that causes the severe respiratory illness COVID-19 is the
worst health crisis that the United States has faced in a century. Although this highly
contagious virus has infected millions of Americans already, the disease burdens are
disproportionately born by historically... expand
The global SARS-CoV-2 pandemic that causes the severe respiratory illness COVID-19 is the worst health crisis that the United States has faced in a century. Although this highly contagious virus has infected millions of Americans already, the disease burdens are disproportionately born by historically underserved populations such as Latinx communities. In Oregon, 13% of the population that is Latinx represents approximately 25.7% of COVID-19 cases and are burdened with more than twice the cases per 100,000 individuals compared to non-Hispanic Oregonians (10,677 versus 4,616, respectively). Furthermore, only 54.9% of eligible Latinx Oregonians are vaccinated compared to the 76.2% statewide vaccination rate. An urgent need exists to reach Oregon's Latinx community to prevent SARS-CoV-2 transmission and increase vaccine acceptance. The overall goal of this study is to implement a Promotores de Salud behavioral health intervention to increase the reach, access, uptake, and impact of testing and vaccination in Latinx communities in Oregon. This project will fully integrate with the National institutes of Health (NIH) Rapid Acceleration of Diagnostics (RADx) consortium and its Coordination and Data Collection Center (CDCC). The study team will add testing venues based on feedback from the Oregon Health Authority (OHA) and our county and community partners to test if a "partner-optimized venue placement strategy" yields more Latinx individuals tested than placement of sites based upon residential density used in the ongoing testing in Phase I of this study (Clinical Trial ID: NCT04793464). In addition, evaluation of the Promotores de Salud intervention held during testing events will test whether culturally competent education results in greater use of strategies that reduce transmission of COVID-19 at the community and individual level and increases the number of individuals who choose to be vaccinated, as a function of fidelity of the intervention. Over time, this project will help communities institutionalize optimal local testing frameworks supported by University of Oregon laboratory facilities for testing capacity, technical support for testing logistics, and collection of data on health behaviors, testing rates, and sustainability. The resulting structures and systems will be poised for future scale-up to other vulnerable communities and/or for other public health purposes. Type: Interventional Start Date: Sep 2021 |
Autoimmune Intervention Mastery Course Study
Terry L. Wahls
Multiple Sclerosis
Clinically Isolated Syndrome
Fibromyalgia
Post Acute Sequelae of COVID-19
Cancer in Remission With Persisting Fatigue
The goal of this project is to critically evaluate the effectiveness of using an online
program to improve diet and self-care in patients with multiple sclerosis (MS),
clinically isolated syndrome (CIS), fibromyalgia, post acute sequela of covid, and cancer
in remission with persisting fatigue. expand
The goal of this project is to critically evaluate the effectiveness of using an online program to improve diet and self-care in patients with multiple sclerosis (MS), clinically isolated syndrome (CIS), fibromyalgia, post acute sequela of covid, and cancer in remission with persisting fatigue. Type: Interventional Start Date: Dec 2021 |
The Impact of COVID-19 on Pulmonary Procedures
M.D. Anderson Cancer Center
COVID-19 Infection
Hematopoietic and Lymphoid Cell Neoplasm
Malignant Solid Neoplasm
This study investigates the changes in practice by pulmonary procedural programs across
the United States as they faced the coronavirus pandemic. Information gathered from this
study may help guide pulmonary programs on a wider scale and improve their practice. The
study may also help researchers... expand
This study investigates the changes in practice by pulmonary procedural programs across the United States as they faced the coronavirus pandemic. Information gathered from this study may help guide pulmonary programs on a wider scale and improve their practice. The study may also help researchers understand where they should focus research efforts to better respond to a pandemic in the future. Type: Observational Start Date: Nov 2020 |
Assessing the Efficacy of Sirolimus in Patients With COVID-19 Pneumonia for Prevention of Post-COVID...
University of Chicago
Pulmonary Fibrosis
COVID-19 Pneumonia
Long COVID
The primary purpose of this study is to determine whether the drug sirolimus reduces the
likelihood of developing of pulmonary fibrosis in patients who are hospitalized with
COVID-19 pneumonia. expand
The primary purpose of this study is to determine whether the drug sirolimus reduces the likelihood of developing of pulmonary fibrosis in patients who are hospitalized with COVID-19 pneumonia. Type: Interventional Start Date: Jul 2021 |
Use of Behavioral Economics in Repeat SARS-CoV-2 (COVID-19) Antibody Testing in Disadvantaged Communities
University of Southern California
SARS-CoV-2
Repeat testing for SARS-CoV-2 antibodies in disadvantaged communities will help identify
active and recovered infections over time, and as more is understood about antibody
protection, it may help identify persons who have immunity. Many questions about social
barriers and behavioral facilitators... expand
Repeat testing for SARS-CoV-2 antibodies in disadvantaged communities will help identify active and recovered infections over time, and as more is understood about antibody protection, it may help identify persons who have immunity. Many questions about social barriers and behavioral facilitators remain unanswered. This project aims to evaluate the effectiveness of risk-based messaging and incentives that promote repeated testing for SARS-CoV-2 antibodies, as well as to understand social and behavioral determinants of COVID-19 testing and variations within sub-groups of this population. Type: Interventional Start Date: Jun 2021 |
Low-dose Tocilizumab Versus Standard of Care in Hospitalized Patients With COVID-19
University of Chicago
COVID-19
Tocilizumab is an effective treatment for severe coronavirus disease 2019 (Covid-19)
pneumonia and related inflammation. Given limited global supplies, clarification of the
optimal tocilizumab dose is critical. We conducted an open-label, randomized, controlled
trial evaluating two different dose... expand
Tocilizumab is an effective treatment for severe coronavirus disease 2019 (Covid-19) pneumonia and related inflammation. Given limited global supplies, clarification of the optimal tocilizumab dose is critical. We conducted an open-label, randomized, controlled trial evaluating two different dose levels of tocilizumab in Covid-19 (40mg and 120mg). Randomization was stratified on remdesivir and corticosteroid at enrollment. The primary outcome was the time to recovery. The key secondary outcome was 28-day mortality. Type: Interventional Start Date: Sep 2020 |
Saved From COVID-19 - Chloroquine (CQ) Prophylaxis for Health Care Workers at Risk for COVID
Columbia University
COVID
Coronavirus Infection
The primary objective is to determine the clinical efficacy of Chloroquine (CQ) in health
care workers with moderate to high risk of exposure to COVID-19 in preventing symptomatic
COVID-19 infections. Secondary endpoints will explore the efficacy of CQ in preventing
any infection as defined by seroconversion... expand
The primary objective is to determine the clinical efficacy of Chloroquine (CQ) in health care workers with moderate to high risk of exposure to COVID-19 in preventing symptomatic COVID-19 infections. Secondary endpoints will explore the efficacy of CQ in preventing any infection as defined by seroconversion to positive anti-COVID antibody status. Type: Interventional Start Date: Apr 2020 |
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
UMC Utrecht
Community-acquired Pneumonia, Influenza, COVID-19
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for
community-acquired pneumonia.
The purpose of this study is to evaluate the effect of a range of interventions to
improve outcome of patients admitted to intensive care with community-acquired pneumonia.
In addition,... expand
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia. The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia. In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic such as COVID-19. REMAP-COVID is a sub-platform of REMAP-CAP that evaluates treatments specific to COVID-19 in the United States of America. Type: Interventional Start Date: Apr 2016 |
Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute...
National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19 Infection
Background:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease
2019 (COVID-19). The global outbreak of COVID-19 is a major public health problem.
COVID-19 causes a wide range of symptoms. These symptoms range from mild breathing
problems to life-threatening... expand
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). The global outbreak of COVID-19 is a major public health problem. COVID-19 causes a wide range of symptoms. These symptoms range from mild breathing problems to life-threatening problems or death. Some people have no symptoms. This study aims to learn how acute and late immune responses to COVID-19 lead to different outcomes. The immune system is the body s defense against germs, including viruses, that invade the body. Objective: To characterize the immune responses during and after SARS-CoV-2 infection and determine if there is any relationship to clinical course and outcome. Eligibility: People ages 0 99 who have confirmed or suspected SARS-CoV-2 infection, people who are not infected despite heavy exposure, and relatives of enrolled participants. Design: This is a sample collection protocol to receive send-in biological specimens for exploratory studies, including gene testing. Participants will not be seen at the NIH for study visits. Study staff will talk with participants health care providers to screen them for the study. Participants enrolled into the protocol will send samples and clinical information at least once and more often if the participant has COVID-19. All participants will provide blood samples and possibly stool. We may also ask for left over specimens from any medical procedures completed as part of medical care. The study staff will also request participants health care providers to complete a survey to collect demographic and medical data. Some of this information may need to be provided directly by the participant. Pregnant individuals are invited to participate and may be asked to give cord blood samples after delivery. Study findings that affect participants health may be shared with their health care provider. Depending on findings, participants may be contacted to take part in other NIH studies. Type: Observational Start Date: Oct 2020 |
Pain Relief With Integrative Medicine (PRIMe)?: Feasibility of Acupuncture for Long COVID
University of Washington
Long COVID
Pain
The goal of this preliminary study is to test methods and procedures to be used in a
fully-powered trial to evaluate acupuncture treatment effectiveness. Specifically, we
will test the feasibility of conducting a 2-arm randomized clinical trial for evaluating
the effectiveness of acupuncture for pain... expand
The goal of this preliminary study is to test methods and procedures to be used in a fully-powered trial to evaluate acupuncture treatment effectiveness. Specifically, we will test the feasibility of conducting a 2-arm randomized clinical trial for evaluating the effectiveness of acupuncture for pain in patients with long COVID. Researchers will compare pain intensity and impact on general activities over 5 months in those who receive acupuncture treatment compared to patients who are receiving usual long COVID care. Participants will complete 4 online surveys at weeks 0, 4, 8, and 20. These surveys include validated mental and physical health questionnaires. Participants who are randomly selected to receive the intervention will receive 8 acupuncture treatment sessions. Type: Interventional Start Date: Jun 2024 |
COVID-19 SARS-CoV-2 RAST Study
Columbia University
SARS-CoV2 Infection
The SARS-CoV-2 BioMedomics Rapid Antigen Screening Test (COV-SCAN) is an at-home rapid
antigen COVID-19 antigen screening test device. The primary objectives of this study are
to 1) Evaluate the clinical performance of COV-SCAN; 2.) Assess the usability of COV-SCAN
and the paired app as an over-the-counter... expand
The SARS-CoV-2 BioMedomics Rapid Antigen Screening Test (COV-SCAN) is an at-home rapid antigen COVID-19 antigen screening test device. The primary objectives of this study are to 1) Evaluate the clinical performance of COV-SCAN; 2.) Assess the usability of COV-SCAN and the paired app as an over-the-counter product to be used by lay persons in non- laboratory settings. The clinical performance and usability data will be submitted as part of an application for Emergency Use Authorization (EUA) to the FDA. 3) Assess acceptability and feasibility of the COV-SCAN test, paired app, and frequent testing regimen in demonstration projects in university and workforce settings. Type: Observational Start Date: Jan 2021 |
RECOVER-ENERGIZE Platform Protocol
Duke University
Long COVID
Long Covid19
Long Covid-19
This is a platform protocol designed to be flexible so that it is suitable for a range of
interventions and settings within diverse health care systems and community settings with
incorporation into clinical COVID-19 management programs and treatment plans if results
achieve key study outcomes.
This... expand
This is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical COVID-19 management programs and treatment plans if results achieve key study outcomes. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating interventions to address and improve exercise intolerance and post-exertional malaise (PEM) as manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). The focus of this protocol is to assess interventions that can improve exercise capacity, daily activities tolerance, and quality of life in patients with PASC. Type: Interventional Start Date: Jul 2024 |
RECOVER-AUTONOMIC: Platform Protocol, Appendix A (IVIG)
Kanecia Obie Zimmerman
Long COVID
Long Coronavirus Disease 2019 (Covid19)
Long Covid-19
This study is a platform protocol designed to be flexible so that it is suitable for a
wide range of settings within health care systems and in community settings where it can
be integrated into COVID-19 programs and subsequent treatment plans.
This protocol is a prospective, multi-center, multi-arm,... expand
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating various interventions for use in the treatment of autonomic dysfunction symptoms, including cardiovascular complications and postural orthostatic tachycardia syndrome (POTS), in Post-Acute Sequelae of SARS-CoV-2 infection (PASC) participants. The interventions tested will include non-pharmacologic care and pharmacologic therapies with study drugs. Type: Interventional Start Date: Mar 2024 |
Lithium Long COVID Dose-finding Study
State University of New York at Buffalo
Long COVID
This open-label study will assess if lithium dosages of 30-45mg/day are associated with
greater symptomatic benefit than dosages of 10-15mg/day previously assessed among 50
patients with long COVID. expand
This open-label study will assess if lithium dosages of 30-45mg/day are associated with greater symptomatic benefit than dosages of 10-15mg/day previously assessed among 50 patients with long COVID. Type: Interventional Start Date: Oct 2023 |
Directed Topical Drug Delivery for Treatment for PASC Hyposmia
Duke University
Post Acute Sequelae Covid-19 Hyposmia
This is a phase II randomized, double-blinded, placebo-controlled study to evaluate the
efficacy of topical intranasal treatment of beclomethasone vs. placebo for improved
olfactory function. expand
This is a phase II randomized, double-blinded, placebo-controlled study to evaluate the efficacy of topical intranasal treatment of beclomethasone vs. placebo for improved olfactory function. Type: Interventional Start Date: Sep 2023 |
Macrophage Regulation of Ozone-Induced Lung Inflammation
Robert Tighe, MD
SARS-CoV-2 Pneumonia
The purpose of this research study to understand how prior respiratory infections affect
the susceptibility to lung inflammation following environmental exposures. expand
The purpose of this research study to understand how prior respiratory infections affect the susceptibility to lung inflammation following environmental exposures. Type: Interventional Start Date: May 2023 |
Long Haul COVID Rehabilitation & Recovery Research Program
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Post-Acute COVID-19 Syndrome
The purpose of the study is to assess the physiologic, immunologic, and mental health
effects of a rehabilitation program on patients with Long Haul COVID (LHC). expand
The purpose of the study is to assess the physiologic, immunologic, and mental health effects of a rehabilitation program on patients with Long Haul COVID (LHC). Type: Interventional Start Date: Feb 2022 |
A Study to Compare S-217622 With Placebo in Non-Hospitalized Participants With COVID-19
Shionogi
SARS-CoV-2 Infection
The main aim of this study is to evaluate the efficacy of S-217622 versus placebo among
outpatient adults with mild and moderate COVID-19 starting intervention within 3 days of
symptom onset. expand
The main aim of this study is to evaluate the efficacy of S-217622 versus placebo among outpatient adults with mild and moderate COVID-19 starting intervention within 3 days of symptom onset. Type: Interventional Start Date: Aug 2022 |
Conversations You Want About Corona Virus Disease (COVID-19)
Wake Forest University Health Sciences
Covid19
Web-enabled virtual topical guide: develop virtual conversations for each concern and
intensity level expand
Web-enabled virtual topical guide: develop virtual conversations for each concern and intensity level Type: Observational Start Date: Mar 2022 |
Resilience and Brain Health of Older Adults During the COVID-19 Pandemic (MEDEX-2)
Washington University School of Medicine
Age-related Cognitive Decline
This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in
conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging
variables already collected at multiple time points in older adults participating in a
clinical trial of exercise and mindfulness.... expand
This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change. Type: Interventional Start Date: Apr 2019 |
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