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Motivation, Syringe Exchange, and COVID-19
University of Oregon
COVID-19 Pandemic
People who inject drugs (PWIDs) are highly vulnerable to SARS-CoV-2 infection and to the
disease caused by SARS-CoV-2, coronavirus disease 2019 (COVID-19), however, rates of
SARS-CoV-2 testing and vaccination uptake -vital to mitigating the spread of COVID-19 and
achieving herd immunity - are lower... expand
People who inject drugs (PWIDs) are highly vulnerable to SARS-CoV-2 infection and to the disease caused by SARS-CoV-2, coronavirus disease 2019 (COVID-19), however, rates of SARS-CoV-2 testing and vaccination uptake -vital to mitigating the spread of COVID-19 and achieving herd immunity - are lower among PWIDs compared to the general population. Building on our Phase I Rapid Acceleration of Diagnostics project, which found that contingency management (CM) increased testing utilization among PWIDs, the proposed project evaluates the comparative effectiveness of CM versus CM plus a brief motivational enhancement intervention on SARS-CoV-2 testing and vaccination uptake among PWIDs. This project has the potential to reduce COVID-19 health disparities among PWIDs and to decrease population level COVID-19 morbidity and mortality. Type: Interventional Start Date: Aug 2022 |
Addressing Vaccine Hesitancy and Increasing COVID-19 Vaccine Uptake Among African American Young Adults...
Florida State University
COVID-19
Vaccine Uptake
The study staff will conduct a hybrid type 1 effectiveness implementation 2-arm trail
with 360 Black young adults from Alabama, Georgia, and North Carolina. Participants will
be randomized to receive the standard of care (control) or the TT-C intervention arm,
each with a balance of 180 participants.... expand
The study staff will conduct a hybrid type 1 effectiveness implementation 2-arm trail with 360 Black young adults from Alabama, Georgia, and North Carolina. Participants will be randomized to receive the standard of care (control) or the TT-C intervention arm, each with a balance of 180 participants. Primary effectiveness outcome is COVID-19 vaccine uptake define as receipt of any vaccine (primary series or secondary booster). Secondary effectiveness outcomes are vaccine hesitancy, confidence, and knowledge, attitudes, and beliefs. The study staff will also conduct qualitative interviews with a group of purposively selected AA-YA participants (est. n=12-16) and site staff (est. n=6-8) to assess barriers and facilitators to implementation. The hypothesis is that the intervention arm will be more effective than the control arm at increasing vaccine uptake. Type: Interventional Start Date: Mar 2023 |
Food Environment, Food Insecurity, and Health Behaviors in NH Hispanics
University of New Hampshire
Obesity
Food Insecurity
This telephone-based survey included adults of Hispanic/Latino background residing in New
Hampshire (NH). Information on food security and access, food environment, and health
status and behaviors was collected through validated questionnaires. This project
addresses the need for assessment of barriers... expand
This telephone-based survey included adults of Hispanic/Latino background residing in New Hampshire (NH). Information on food security and access, food environment, and health status and behaviors was collected through validated questionnaires. This project addresses the need for assessment of barriers to nutrition and health during COVID-19 in this population. Type: Observational Start Date: Oct 2021 |
Post-Acute Sequelae of Coronavirus-19 (COVID-19) With Dyspnea on Exertion And Associated TaChycardia...
Hackensack Meridian Health
Tachycardia
Dyspnea
COVID-19
Most patients with acute COVID-19 (Coronavirus 19) recover within weeks, however a
significant number of individuals will develop the post-acute COVID 19 syndrome (PASC).
As of July 2021, the post COVID syndrome qualifies as a disability under the Americans
with Disabilities Act. The symptoms which... expand
Most patients with acute COVID-19 (Coronavirus 19) recover within weeks, however a significant number of individuals will develop the post-acute COVID 19 syndrome (PASC). As of July 2021, the post COVID syndrome qualifies as a disability under the Americans with Disabilities Act. The symptoms which comprise this condition are highly variable and often extraordinarily debilitating. They may be distinct from the initial presentation or may mimic those which defined the initial infection. The post COVID syndrome can be diagnosed when symptoms persist longer than 3 months and may extend to beyond one year. There are risks for permanent levels of disability. Patients who seemingly did not have active COVID-19 symptoms in the days following infectious exposure may also develop post Covid syndromes. These syndromes are considered to constitute a distinct clinical entity which has of yet no clearly defined pathogenic mechanism or validated treatment algorithms. International investigative efforts are now underway to determine who might develop the post COVID syndrome, it's long term consequences and how best to treat its many problematic symptoms. Type: Interventional Start Date: Mar 2022 |
COVID-19 Vaccine Response in Treated MS Patients
Brigham and Women's Hospital
Multiple Sclerosis
Healthy
The primary goal of this study is to assess the impact of the two major disease modifying
therapy (DMT) classes (B cell therapies and S1P modulators) on humoral and cell-mediated
immunity to SARS- CoV-2 vaccination compared to non-MS controls. We have chosen to
compare DMT-treated MS patients to non-MS... expand
The primary goal of this study is to assess the impact of the two major disease modifying therapy (DMT) classes (B cell therapies and S1P modulators) on humoral and cell-mediated immunity to SARS- CoV-2 vaccination compared to non-MS controls. We have chosen to compare DMT-treated MS patients to non-MS controls because the pivotal vaccine studies were conducted in non-MS healthy control groups in which there is significant clinical data and validated assays for antibody responses. Type: Observational Start Date: Jun 2021 |
Leveraging Social Networks to Increase COVID-19 Testing Uptake
New York State Psychiatric Institute
Covid-19
Substance Use
Opioid Use
This two-year project will adapt and conduct a trial examining the ability of two
recruitment strategies, chain-referral and credible messenger, to reach those who use
opioids and other substances in order to increase their uptake of onsite point of care
COVID-19 testing that will be delivered in... expand
This two-year project will adapt and conduct a trial examining the ability of two recruitment strategies, chain-referral and credible messenger, to reach those who use opioids and other substances in order to increase their uptake of onsite point of care COVID-19 testing that will be delivered in two community based organizations (CBOs): Alliance for Positive Change and Argus Health Inc. In Phase 1, Adapt two implementation strategies to support COVID-19 testing uptake and sustainability, adapting elements of existing efficacious social network-based interventions via a CBPR approach. In Phase 2, we will examine and compare the efficacy of two sets of implementation strategies on (i) reach, (ii) testing uptake, (iii) service delivery (i.e. quarantine, medical care, contact tracing) and (iv) sustainability for individuals who use opioids and other drugs. In Phase 3, Elucidate and compare the system/organizational-, staff-, and individual-level factors that influence implementation (i.e. fidelity, acceptability, feasibility, sustainability) of the strategies to develop a plan for dissemination and scale-up in other CBOs who serve opioid and other substance using individuals in NYC. Type: Interventional Start Date: Apr 2021 |
Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19
The Cleveland Clinic
Alcoholic Liver Disease
COVID 19 Pneumonia
Patients with COVID-19 and comorbidities including alcohol associated liver disease (ALD)
are at risk for severe illness and abrupt or sudden clinical deterioration with
ventilatory failure. â-hydroxy â-methyl butyrate (HMB), a non-nitrogenous leucine
metabolite with anabolic properties, increases... expand
Patients with COVID-19 and comorbidities including alcohol associated liver disease (ALD) are at risk for severe illness and abrupt or sudden clinical deterioration with ventilatory failure. â-hydroxy â-methyl butyrate (HMB), a non-nitrogenous leucine metabolite with anabolic properties, increases muscle mass and contractile function and enhances immune function. We aim to study the natural course of COVID-19 in patients with ALD and test whether HMB can affect ventilatory deterioration and improve short and long-term morbidity, mortality, and recovery from critical illness in symptomatic COVID-19 patients with ALD. Type: Interventional Start Date: Apr 2021 |
The COVID-19 Back-to-Normal Study: Analysis of Multiple Outcomes
Mebo Research, Inc.
COVID-19 Vaccines
During the study, members of different online and offline communities will be followed
post COVID-19 vaccination.
Injection-site (local) and systemic reaction data will be assessed on vaccination day and
afterwards using either web surveys or personal communication, depending on study
participant... expand
During the study, members of different online and offline communities will be followed post COVID-19 vaccination. Injection-site (local) and systemic reaction data will be assessed on vaccination day and afterwards using either web surveys or personal communication, depending on study participant preference. Hypothesis to be tested: The safety profile and the magnitude and durability of immune responses to the COVID-19 vaccines as well as adverse reactions depend on health conditions, metabolism and microbiomes. Type: Observational Start Date: Jan 2021 |
Solve Together: A Data Collection Platform for the Collection of Patient and Control Health Information...
Solve ME/CFS Initiative
Post-Acute COVID-19 Syndrome
ME/CFS
Solve Together is a platform designed to collect clinical data about post-infectious
diseases, including ME/CFS and Long Covid. This data is made available to researchers and
will be used to identify participants eligible for clinical studies. The platform also
empowers patients to make reports for... expand
Solve Together is a platform designed to collect clinical data about post-infectious diseases, including ME/CFS and Long Covid. This data is made available to researchers and will be used to identify participants eligible for clinical studies. The platform also empowers patients to make reports for their doctors, connect medical records and/or a health-tracking wearable device, and identify their unique symptoms and health patterns. Type: Observational [Patient Registry] Start Date: Jul 2023 |
Improving Health Equity for COVID-19 Vaccination for At-risk Populations Using Online Social Networks
University of Pennsylvania
Vaccination Refusal
Covid19
Heart Diseases
Social technologies for health have already become essential means for providing
underserved populations greater social connectedness and increased access to novel health
information. However, these technologies have also had negative unintended consequences.
The resulting digital divide in social... expand
Social technologies for health have already become essential means for providing underserved populations greater social connectedness and increased access to novel health information. However, these technologies have also had negative unintended consequences. The resulting digital divide in social technology takes many forms - from explicit racism that excludes African American and Latinx populations from the resources enjoyed by White and Asian members of online communities, to self-segregation for the purposes of identity preservation and community-building that unintentionally results in limited informational diversity in underserved communities. The result is an often unnoticed, but highly consequential compounding of inequities. This research seeks to use an online social network approach to address these challenges, in which the investigators demonstrate how reducing the online levels of network centralization and network homophily among African American community members directly increases their productive engagement with health-promoting information. Type: Interventional Start Date: May 2021 |
REmotely Monitored, Mobile Health-Supported High Intensity Interval Training After COVID-19 Critical...
Duke University
Covid19
Critical Illness
High Intensity Interval Training
ICU
Intensive Care Units
REmotely Monitored, Mobile Health-Supported High Intensity Interval Training after
COVID-19 critical illness (REMM-HIIT-COVID-19) expand
REmotely Monitored, Mobile Health-Supported High Intensity Interval Training after COVID-19 critical illness (REMM-HIIT-COVID-19) Type: Interventional Start Date: Mar 2022 |
Safety and Efficacy of Melatonin in Outpatients Infected With COVID-19
State University of New York at Buffalo
COVID-19
This study is a pilot randomized, double-blind, placebo-controlled clinical trial to
evaluate the safety and efficacy of melatonin in adult outpatients suspected to be
afflicted with COVID-19. expand
This study is a pilot randomized, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of melatonin in adult outpatients suspected to be afflicted with COVID-19. Type: Interventional Start Date: Nov 2020 |
PET/CT Imaging in COVID-19 Patients
University of California, Davis
COVID-19
SARS-CoV-2 Infection
This is a PET/CT study using the 18F-αvβ6-binding-peptide.The goal of this study is to
evaluate this peptide in patients after infection with SARS CoV2. expand
This is a PET/CT study using the 18F-αvβ6-binding-peptide.The goal of this study is to evaluate this peptide in patients after infection with SARS CoV2. Type: Interventional Start Date: May 2020 |
VIR-7831 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19
This study looks at the safety and effectiveness of VIR-7831 in treating COVID-19 in
people who have been hospitalized with the infection. Participants in the study will be
treated with either VIR-7831 plus current standard of care (SOC), or with placebo plus
current SOC. This is ACTIV-3/TICO Treatment... expand
This study looks at the safety and effectiveness of VIR-7831 in treating COVID-19 in people who have been hospitalized with the infection. Participants in the study will be treated with either VIR-7831 plus current standard of care (SOC), or with placebo plus current SOC. This is ACTIV-3/TICO Treatment Trial H2. Type: Interventional Start Date: Dec 2020 |
Collection of SARS CoV-2 (COVID-19) Virus Secretions and Serum for Countermeasure Development
Tulane University
Covid19
Collection of SARS-COV-2 Secretions and Serum for Countermeasure Development (aka
ClinSeqSer) is an observational study to understand natural history of SARS-COV-2
infections among special populations and characterise post-covid morbidity through immune
response, virus genome sequencing, cytokine... expand
Collection of SARS-COV-2 Secretions and Serum for Countermeasure Development (aka ClinSeqSer) is an observational study to understand natural history of SARS-COV-2 infections among special populations and characterise post-covid morbidity through immune response, virus genome sequencing, cytokine response, and virus shedding. Given the descriptions of infection course of patients over the outbreak of 2003 (SARS-Cov01) and since January 2019 in China and Europe, and now worldwide: 1. Acutely infected patients shed virus that could be of major interest to characterize (viral quantification, characterization of virus shedding -of infective and of non-infective virus) the former reflecting/predictive of severity of disease and the latter reflecting extent/source of contagiosity. 2. Convalescent infected patients develop a specific anti-virus antibody response that is (likely) protective and therefore suits the preliminary requirement for the potential benefits of the convalescent patient plasma therapeutic infusion approach. In addition, long term effects of COVID-19 commonly known as long-haulers remains clinically unclear. Thousands of patients have now been diagnosed with COVID-19 in Louisiana (444,000 cases, 10,122 deaths, 2.2% mortality in Louisiana (LA), as of March 2021), and numerous patients are now also complaining of post-acute sequelae of SARS-CoV-2 (PASC). The investigators want to further clarify questions surrounding rational confinement duration and therapeutic approach by collecting plasma of convalescent patients to identify optimal antibody titer by ELISA, specificity of naturally occurring inflammatory (protein/antibody and RNA) response, and possibly test in vitro antibody neutralization activity. Type: Observational Start Date: Mar 2020 |
Impact of LA-CEAL HALT COVID-19 Ambassador Program on Likelihood to Vaccinate
Tulane University
Covid19
Vaccine Refusal
The purpose of the study is to assess the effectiveness of the HALT COVID Ambassador
educational outreach program on increasing likelihood to vaccinate against COVID-19 expand
The purpose of the study is to assess the effectiveness of the HALT COVID Ambassador educational outreach program on increasing likelihood to vaccinate against COVID-19 Type: Interventional Start Date: Oct 2021 |
A Study to Evaluate the Immunogenicity and Safety of mRNA Vaccine Boosters for SARS-CoV-2 (COVID-19)...
ModernaTX, Inc.
SARS-CoV-2
This is a study to evaluate the immunogenicity, safety, and reactogenicity of
mRNA-1273.211, mRNA-1273, mRNA-1273.617.2, mRNA-1273.213, mRNA-1273.529, mRNA-1273.214,
mRNA-1273.222, mRNA-1273.815, and mRNA-1273.231 administered as booster doses. expand
This is a study to evaluate the immunogenicity, safety, and reactogenicity of mRNA-1273.211, mRNA-1273, mRNA-1273.617.2, mRNA-1273.213, mRNA-1273.529, mRNA-1273.214, mRNA-1273.222, mRNA-1273.815, and mRNA-1273.231 administered as booster doses. Type: Interventional Start Date: May 2021 |
Use of Construal Level Theory to Inform Messaging to Increase Vaccination Against COVID-19
Brigham and Women's Hospital
Covid19
Vaccine Refusal
This study aims to increase uptake of the COVID booster vaccine through messaging
informed by Construal Level Theory. Patients in the Mass General Brigham (MGB) health
system aged 18 and older who are eligible for the COVID booster vaccine, but who have not
yet received a dose at the time of an upcoming... expand
This study aims to increase uptake of the COVID booster vaccine through messaging informed by Construal Level Theory. Patients in the Mass General Brigham (MGB) health system aged 18 and older who are eligible for the COVID booster vaccine, but who have not yet received a dose at the time of an upcoming primary care clinic visit, will be randomized to one of three messaging arms: 1) "why" messaging, 2) "how" messaging, or 3) standard of care ("usual care"). Messages will be sent via the electronic patient portal a few days in advance of their office visit. The primary outcome will be the rate of booster vaccination at the targeted visit. The secondary outcome will be the rate of receipt of a COVID booster vaccine within 6 weeks of the targeted visit. Subgroup analyses to assess for any association of patient characteristics with intervention responsiveness will be exploratory. Type: Interventional Start Date: Feb 2022 |
COVID-19 Close Contact Self-Testing Study
University of Pennsylvania
Covid19
Widespread testing and contact tracing are critical to controlling the COVID-19 epidemic.
Distribution of COVID-19 self-test kits can augment public health contact tracing
efforts, as individuals with COVID-19 can distribute self-testing to close contacts. This
approach can increase case detection... expand
Widespread testing and contact tracing are critical to controlling the COVID-19 epidemic. Distribution of COVID-19 self-test kits can augment public health contact tracing efforts, as individuals with COVID-19 can distribute self-testing to close contacts. This approach can increase case detection by facilitating testing among exposed individuals, and potentially ameliorate stigma, fear, and medical mistrust associated with COVID-19 among vulnerable populations. The central hypothesis of this study is that distribution of SARS-CoV-2 self-tests to close contacts of among individuals with COVID-19 infection can increase case detection compared with a standard contact referral strategy. Type: Interventional Start Date: May 2021 |
Vitamin D3 Supplementation to Prevent Respiratory Tract Infections
The Cooper Health System
Respiratory Tract Infections
Covid19
Flu Like Illness
The Cooper vitamin D3 study is a randomized study investigating whether daily vitamin D3
supplementation can prevent respiratory tract infections, influenza-like illness and
covid-19 in hospital workers. expand
The Cooper vitamin D3 study is a randomized study investigating whether daily vitamin D3 supplementation can prevent respiratory tract infections, influenza-like illness and covid-19 in hospital workers. Type: Interventional Start Date: Oct 2020 |
Performance Evaluation of LumiraDx COVID-19 (SARS-CoV-2) Ag Test
LumiraDx UK Limited
Covid19
Performance of the LumiraDx SARS-CoV-2 Ag assay will be assessed by comparison to a
reference method. expand
Performance of the LumiraDx SARS-CoV-2 Ag assay will be assessed by comparison to a reference method. Type: Interventional Start Date: Jun 2020 |
LSALT Peptide vs. Placebo to Prevent ARDS and Acute Kidney Injury in Patients Infected With SARS-CoV-2...
Arch Biopartners Inc.
COVID
Severe Acute Respiratory Syndrome
Sars-CoV2
Acute Kidney Injury
Acute Respiratory Distress Syndrome
To evaluate the proportion of subjects alive and free of respiratory failure (e.g. need
for non-invasive or invasive mechanical ventilation, high flow oxygen, or ECMO) and free
of the need for continued renal replacement therapy (RRT) on Day 28. The need for
continued RRT at Day 28 will be defined... expand
To evaluate the proportion of subjects alive and free of respiratory failure (e.g. need for non-invasive or invasive mechanical ventilation, high flow oxygen, or ECMO) and free of the need for continued renal replacement therapy (RRT) on Day 28. The need for continued RRT at Day 28 will be defined as either dialysis in the past 3 days (Day 26, 27, or 28) or an eGFR on Day 28 <10 mL/min/1.73 m2. Type: Interventional Start Date: Oct 2020 |
Home Usability Study of the SARS-CoV-2 (COVID-19) Test
Exact Sciences Corporation
COVID-19
The primary objective is to determine the usability of the SARS-CoV-2 Specimen Collection
Materials for at-home collection and mailing of sample to the testing laboratory. expand
The primary objective is to determine the usability of the SARS-CoV-2 Specimen Collection Materials for at-home collection and mailing of sample to the testing laboratory. Type: Observational Start Date: May 2020 |
Positron Emission Tomography (PET) Imaging of Thrombosis
Massachusetts General Hospital
Atrial Fibrillation
COVID-19
Cancer
Thrombosis
The purpose of the study is to evaluate a new radiotracer called 64Cu-FBP8 for PET-MR
imaging of thrombosis. The tracer has the potential of detecting thrombosis anywhere in
the body, for instance in the left atrial appendage of patients with atrial fibrillation,
and thereby may provide a non-invasive... expand
The purpose of the study is to evaluate a new radiotracer called 64Cu-FBP8 for PET-MR imaging of thrombosis. The tracer has the potential of detecting thrombosis anywhere in the body, for instance in the left atrial appendage of patients with atrial fibrillation, and thereby may provide a non-invasive alternative to the current standard-of-care methods. Type: Interventional Start Date: Apr 2016 |
High Resolution Micro OCT Imaging
University of Alabama at Birmingham
Cystic Fibrosis
COPD
PCD - Primary Ciliary Dyskinesia
Covid19
Sinusitis
The purpose of this study is to learn about using the imaging to make images of the lungs
and nose with the long-term goal of the research leading to potential treatments and new
therapies for patients with cystic fibrosis. expand
The purpose of this study is to learn about using the imaging to make images of the lungs and nose with the long-term goal of the research leading to potential treatments and new therapies for patients with cystic fibrosis. Type: Observational Start Date: Apr 2016 |
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