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A Dose Finding, Efficacy and Safety Study of Ensovibep (MP0420) in Ambulatory Adult Patients With Symptomatic...
Novartis Pharmaceuticals
COVID-19
The purpose of this study is to establish the antiviral efficacy of ensovibep against
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, identify the
optimal dose, and demonstrate its clinical value for treating COVID-19 in adult
ambulatory patients. expand
The purpose of this study is to establish the antiviral efficacy of ensovibep against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, identify the optimal dose, and demonstrate its clinical value for treating COVID-19 in adult ambulatory patients. Type: Interventional Start Date: May 2021 |
The Evaluation of Nitric Oxide Generating Lozenges on Outcome in Newly Diagnosed COVID-19 Patient of...
Nitric Oxide Innovations LLC
COVID-19
This study is a multi-center, randomized, double blinded, prospective, placebo controlled
study. Patients upon diagnosis of COVID-19 (Corona Virus Disease-19) will be eligible to
participate in the study. The purpose of this study is to find out the side effects and
ability to take the study drug,... expand
This study is a multi-center, randomized, double blinded, prospective, placebo controlled study. Patients upon diagnosis of COVID-19 (Corona Virus Disease-19) will be eligible to participate in the study. The purpose of this study is to find out the side effects and ability to take the study drug, Nitric Oxide (NO) lozenges when taken twice daily by mouth. If this study shows that the drug has no or few, acceptable side effects, it will then include up to 840 participants to find out if the drug can reduce bad outcomes of COVID-19 infection (hospitalization, ICU admission, death). In each part of the study, half of the subjects will receive the study drug and the other half will be given a placebo (inactive pill). Type: Interventional Start Date: Nov 2020 |
Study of the Efficacy and Safety of STI-5656 (Abivertinib Maleate) in Subjects Hospitalized With COVID-19
Sorrento Therapeutics, Inc.
Covid-19
Study to assess the safety and efficacy of STI-5656 (Abivertinib Maleate) plus SOC versus
SOC in subjects hospitalized with COVID-19 expand
Study to assess the safety and efficacy of STI-5656 (Abivertinib Maleate) plus SOC versus SOC in subjects hospitalized with COVID-19 Type: Interventional Start Date: Oct 2020 |
Dose-Confirmation Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1273 COVID-19...
ModernaTX, Inc.
SARS-CoV-2
This clinical study will assess the safety, reactogenicity, and immunogenicity of 2 dose
levels of mRNA-1273 Severe Acute Respiratory Syndrome coronavirus (SARS-COV-2) vaccine in
adults 18 years of age or older. expand
This clinical study will assess the safety, reactogenicity, and immunogenicity of 2 dose levels of mRNA-1273 Severe Acute Respiratory Syndrome coronavirus (SARS-COV-2) vaccine in adults 18 years of age or older. Type: Interventional Start Date: May 2020 |
Anti-SARS Cov-2 T Cell Infusions for COVID 19
Baylor College of Medicine
SARS-CoV 2
Viral Infection
COVID 19
This is a dose-finding safety trial followed by a randomized pilot trial comparing
administration of SARS-CoV2-specific T cells (SARS-CoVSTs) to standard of care treatment
in hospitalized patients with COVID19 who are at high risk of requiring mechanical
ventilation.
The SARS-CoVSTs lines have... expand
This is a dose-finding safety trial followed by a randomized pilot trial comparing administration of SARS-CoV2-specific T cells (SARS-CoVSTs) to standard of care treatment in hospitalized patients with COVID19 who are at high risk of requiring mechanical ventilation. The SARS-CoVSTs lines have been made at Baylor College of Medicine from healthy donors who have made a full recovery from COVID19. These cell lines were frozen for later use and will be thawed and used to treat patients who meet the eligibility criteria. Type: Interventional Start Date: Nov 2020 |
Inhaled NO for the Treatment of COVID-19 Caused by SARS-CoV-2 (US Trial)
Beyond Air Inc.
Corona Virus Infection
COVID-19
SARS-CoV 2
Nitric Oxide
Respiratory Disease
The purpose of this open label, randomized, study is to obtain information on the safety
and efficacy of 80 ppm Nitric Oxide given in addition to the standard of care of patients
with COVID-19 caused by SARS-CoV-2. expand
The purpose of this open label, randomized, study is to obtain information on the safety and efficacy of 80 ppm Nitric Oxide given in addition to the standard of care of patients with COVID-19 caused by SARS-CoV-2. Type: Interventional Start Date: Jun 2020 |
Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)
Unity Health Toronto
ARDS
This is a multicenter randomized controlled clinical trial with an adaptive design
assessing the efficacy of setting the ventilator based on measurements of respiratory
mechanics (recruitability and effort) to reduce Day 60 mortality in patients with acute
respiratory distress syndrome (ARDS).
The... expand
This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60 mortality in patients with acute respiratory distress syndrome (ARDS). The CAVIARDS study is also a basket trial; a basket trial design examines a single intervention in multiple disease populations. CAVIARDS consists of an identical 2-arm mechanical ventilation protocol implemented in two different study populations (COVID-19 and non-COVID-19 patients). As per a typical basket trial design, the operational structure of both the COVID-19 substudy (CAVIARDS-19) and non-COVID-19 substudy (CAVIARDS-all) is shared (recruitment, procedures, data collection, analysis, management, etc.). Type: Interventional Start Date: Nov 2020 |
Information Provision and Consistency Framing to Increase COVID-19 Booster Uptake
University of California, Los Angeles
COVID-19
Vaccines
This study investigates different ways to elevate intentions to get the COVID-19 booster
via text-based reminders, including providing information about the booster and
leveraging the consistency principle. The proposed randomized controlled trial will
examine the impact of these reminders on booster... expand
This study investigates different ways to elevate intentions to get the COVID-19 booster via text-based reminders, including providing information about the booster and leveraging the consistency principle. The proposed randomized controlled trial will examine the impact of these reminders on booster uptake. Type: Interventional Start Date: Oct 2022 |
Effects of Prompt to Bundle COVID-19 Booster and Flu Shot
University of California, Los Angeles
COVID-19
Vaccines
This randomized controlled trial investigates whether text-based reminders can increase
the bivalent COVID-19 booster uptake and whether text-based reminders that mention the
opportunity to bundle the COVID-19 booster with the flu shot within the same appointment
can increase take-up of both the COVID-19... expand
This randomized controlled trial investigates whether text-based reminders can increase the bivalent COVID-19 booster uptake and whether text-based reminders that mention the opportunity to bundle the COVID-19 booster with the flu shot within the same appointment can increase take-up of both the COVID-19 booster and the flu vaccine. Type: Interventional Start Date: Oct 2022 |
Safety and Immunogenicity Study of 20vPnC When Coadministered With a Booster Dose of BNT162b2
Pfizer
Pneumococcal Disease
COVID-19
SARS-CoV-2 Infection
Study of the safety and immunogenicity of 20vPnC and a booster dose of BNT162b2
administered at the same visit or each vaccine given alone expand
Study of the safety and immunogenicity of 20vPnC and a booster dose of BNT162b2 administered at the same visit or each vaccine given alone Type: Interventional Start Date: May 2021 |
A Study to Evaluate Safety, Tolerability, & Immunogenicity of Multiple Formulations of BNT162b2 Against...
BioNTech SE
SARS-CoV-2 Infection
COVID-19
This study will compare the safety and tolerability of lyophilized BNT162b2 presented in
single dose vials to those of frozen-liquid BNT162b2 in multidose vials and determine
whether the immune response is noninferior. Separately, the study will also describe the
safety and immunogenicity of frozen-liquid... expand
This study will compare the safety and tolerability of lyophilized BNT162b2 presented in single dose vials to those of frozen-liquid BNT162b2 in multidose vials and determine whether the immune response is noninferior. Separately, the study will also describe the safety and immunogenicity of frozen-liquid BNT162b2 with lipid nanoparticle size at the upper end of specification and ready to use BNT162b2 (the immediate manufacturing precursor to the lyophilate). Additionally, the study will describe the safety and immunogenicity of an additional dose of frozen liquid BNT162b2 to participants who already received the 2-dose schedule of lyophilized BNT162b2. - 2-dose schedule (separated by 21 days) - At a dose of 30µg (as studied in the Phase 2/3 study C4591001) - In healthy adults 18 through 55 years of age - The duration of the study for each participant will be approximately 2 months (3 visits in total) - The study will be conducted in the United States Type: Interventional Start Date: Apr 2021 |
A Phase 3 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Multiple Production Lots...
BioNTech SE
SARS-CoV-2 Infection
COVID-19
This is a Phase 3, randomized, observer-blind study in healthy individuals.
The primary study will evaluate the safety, tolerability, and immunogenicity of the
SARS-CoV-2 RNA vaccine candidate (BNT162b2):
- As a 30-microgram dose, administered from 1 of 4 manufacturing lots (batches)
-... expand
This is a Phase 3, randomized, observer-blind study in healthy individuals. The primary study will evaluate the safety, tolerability, and immunogenicity of the SARS-CoV-2 RNA vaccine candidate (BNT162b2): - As a 30-microgram dose, administered from 1 of 4 manufacturing lots (batches) - As a 20-microgram dose, administered from 1 of the manufacturing lots - As a 2-dose (separated by 21 days) schedule - In people 12 through 50 years of age The booster study will evaluate the safety, tolerability, and immunogenicity of 2 SARS-CoV-2 RNA vaccine candidates (BNT162b2 and BNT162b2.B.1.351): - Each as a 30-microgram dose - Each as a 1-dose booster vaccine, administered approximately 3 months after Dose 2 - In people 18 through 50 years of age Type: Interventional Start Date: Feb 2021 |
Colchicine to Reduce Cardiac Injury in COVID-19 (COLHEART-19)
University of California, Los Angeles
COVID-19
Participants will be randomized in a 1:1 ratio to receive Colchicine plus current care
per UCLA treating physicians versus current care per UCLA treating physicians alone
(control arm). Importantly, this adaptive trial design allows for patients in either
study arm to receive other investigational... expand
Participants will be randomized in a 1:1 ratio to receive Colchicine plus current care per UCLA treating physicians versus current care per UCLA treating physicians alone (control arm). Importantly, this adaptive trial design allows for patients in either study arm to receive other investigational drugs for COVID-19 as new science emerges. Type: Interventional Start Date: May 2020 |
Evaluation of the Clinical Impact of Corticosteroid Duration on SARS-CoV-2 (COVID-19 WHO)
Methodist Health System
Covid 19
The purpose of this project is to evaluate the clinical impact of the use of
glucocorticoids beyond 10 days for patients with critical COVID-19 at MDMC. expand
The purpose of this project is to evaluate the clinical impact of the use of glucocorticoids beyond 10 days for patients with critical COVID-19 at MDMC. Type: Observational Start Date: Oct 2021 |
COVID-19 MP Biomedicals Rapid SARS-CoV-2 Antigen Test Usability
MP Biomedicals, LLC
Sars-CoV-2 Infection
COVID-19
SARS-CoV-2 rapid antigen over the counter usability study. expand
SARS-CoV-2 rapid antigen over the counter usability study. Type: Interventional Start Date: Oct 2021 |
COVID-19 MP Biomedicals SARS-CoV-2 Ag OTC: Clinical Evaluation
MP Biomedicals, LLC
SARS-CoV2 Infection
COVID-19
SARS-CoV-2 rapid antigen over the counter clinical performance evaluation expand
SARS-CoV-2 rapid antigen over the counter clinical performance evaluation Type: Interventional Start Date: Dec 2021 |
Elderberry for Immune Support
Franklin Health Research
Upper Respiratory Tract Infection
COVID-19
Flu
Flu Like Illness
Cold
The purpose of this study is to confirm and quantify the effects of ElderCraft®
elderberry extract on immune health. expand
The purpose of this study is to confirm and quantify the effects of ElderCraft® elderberry extract on immune health. Type: Interventional Start Date: Aug 2022 |
Comparison of EPM-IX to Currently Used Specimen Transportation and Extraction Devices ( CGI-EPM-IX )
Convergent Genomics, Inc.
SARS-CoV-2
This is a research study to evaluate the clinical utility of the Enhanced Preservation
Media with Integrated Extraction (EPM-IX) expand
This is a research study to evaluate the clinical utility of the Enhanced Preservation Media with Integrated Extraction (EPM-IX) Type: Observational Start Date: Feb 2022 |
Impact of Nudges on Downloads of COVID-19 Exposure Notification Smartphone Apps: A Randomized Trial
University of Pennsylvania
COVID-19
Eligible participants who were active beneficiaries of a large insurer living in
Pennsylvania were sent an email encouraging them to download the contact tracing app in
Pennsylvania, COVID Alert PA.
Participants will be randomly assigned to one of four conditions in a 2 (Self-benefit vs.
Other-Benefit)... expand
Eligible participants who were active beneficiaries of a large insurer living in Pennsylvania were sent an email encouraging them to download the contact tracing app in Pennsylvania, COVID Alert PA. Participants will be randomly assigned to one of four conditions in a 2 (Self-benefit vs. Other-Benefit) x 2 (Social Norms Present vs. Social Norms absent) design. All participants received an email that said : "COVID Alert PA is the official Exposure Notification App from the Pennsylvania Department of Health. Join Penn Medicine in the fight against COVID-19 and download COVID Alert PA today!" ---Investigators manipulated the content here--- "The app uses Bluetooth to sense when one person is in close contact with another person with the app. If someone tests positive for COVID-19, and they decide to upload the information to the health department, people who have the app and who have been in contact with them will be alerted. If you are interested in downloading the app, please click COVID Alert PA. We appreciate you joining our efforts. Together we can beat COVID-19!" In the Other-Benefit condition, it said: "It can help you reduce your risk of unknowingly spreading the virus to your friends, family, and larger community." In the Self-Benefit condition, it said: "It can help you determine where and when to get testing, and how to get care if you need it." In the Social Norms Present condition, it said: "Over 650,000 Pennsylvanians have already downloaded the app!" In the Social Norms Absent condition, it said the statement about social norms above. Participants who do not open the initial email received a follow-up email. Type: Interventional Start Date: Dec 2020 |
Nebulized Heparin for COVID19-associated Acute Respiratory Failure
Brittany Bissell
Covid19
The objective of the current study is to investigate the utilization of nebulized heparin
to circumvent pathologic changes in COVID-19 and prevent harmful effects possible with
systemic anticoagulation. expand
The objective of the current study is to investigate the utilization of nebulized heparin to circumvent pathologic changes in COVID-19 and prevent harmful effects possible with systemic anticoagulation. Type: Interventional Start Date: May 2021 |
NOWDx Test for the Detection of Antibodies to COVID-19
NOWDiagnostics, Inc.
COVID-19
SARS-CoV-2
Coronavirus
This study is designed to compare the performance of the NOWDx COVID-19 Test to an
emergency use authorized PCR test result. The intent is to show the rapid test device is
comparable to a currently marketed device. The NOWDx COVID-19 Test is an in vitro lateral
flow immunoassay intended for qualitative... expand
This study is designed to compare the performance of the NOWDx COVID-19 Test to an emergency use authorized PCR test result. The intent is to show the rapid test device is comparable to a currently marketed device. The NOWDx COVID-19 Test is an in vitro lateral flow immunoassay intended for qualitative detection of total antibodies to SARS-CoV-2 in human whole blood (venous and fingerstick). Type: Interventional Start Date: Sep 2020 |
COVID-19 and Venous Thromboembolism Risk
University of California, San Francisco
Venous Thromboembolism
Covid19
Coronavirus disease 2019 (Covid-19) is now a leading cause of death among U.S. adults. In
addition to profound respiratory and multi-organ failure, hypercoagulable states and
venous thromboembolism (VTE) have been increasingly reported in patients with severe
Covid-19. The aim of this study is evaluate... expand
Coronavirus disease 2019 (Covid-19) is now a leading cause of death among U.S. adults. In addition to profound respiratory and multi-organ failure, hypercoagulable states and venous thromboembolism (VTE) have been increasingly reported in patients with severe Covid-19. The aim of this study is evaluate the risk of VTE related to Covid-19 infection in a real-world community-based population. Type: Observational Start Date: Jan 2020 |
VIR-7831 for the Early Treatment of COVID-19 in Outpatients
Vir Biotechnology, Inc.
Covid19
This is a phase 2/3 study in which subjects with coronavirus disease 2019 (COVID-19) will
receive VIR-7831 or placebo and will be assessed for safety, tolerability, efficacy, and
pharmacokinetics. expand
This is a phase 2/3 study in which subjects with coronavirus disease 2019 (COVID-19) will receive VIR-7831 or placebo and will be assessed for safety, tolerability, efficacy, and pharmacokinetics. Type: Interventional Start Date: Aug 2020 |
Detecting SARS-CoV-2 in Tears
University of Minnesota
COVID
COVID-19
Corona Virus Infection
SARS-CoV-2
Purpose:
- To determine the presence of SARS-CoV-2 in tears
- To determine SARS-CoV-2 receptors in tear production system expand
Purpose: - To determine the presence of SARS-CoV-2 in tears - To determine SARS-CoV-2 receptors in tear production system Type: Observational Start Date: Sep 2021 |
Study to Evaluate the Safety and Efficacy of High Dose Intravenous Immune Globulin (IVIG) Plus Standard...
Grifols Therapeutics LLC
COVID-19
The purpose of the study is to determine if a high dose of Intravenous Immune Globulin
(IVIG) plus Standard Medical Treatment (SMT) can reduce all-cause mortality versus SMT
alone in hospitalized participants with COVID-19 requiring admission to the ICU through
Day 29. expand
The purpose of the study is to determine if a high dose of Intravenous Immune Globulin (IVIG) plus Standard Medical Treatment (SMT) can reduce all-cause mortality versus SMT alone in hospitalized participants with COVID-19 requiring admission to the ICU through Day 29. Type: Interventional Start Date: Sep 2020 |
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